新疆医学
新疆醫學
신강의학
Xinjiang Medical Journal
2015年
9期
1226-1228,1231
,共4页
甲氨蝶呤%异位妊娠%治疗结局
甲氨蝶呤%異位妊娠%治療結跼
갑안접령%이위임신%치료결국
Methotrexate%Ectopic pregnancy%Treatment
目的：探讨甲氨蝶呤（Methotrexate MTX）保守治疗采用不同的治疗方案对异位妊娠治疗结局的影响。方法选取我院2010年1月～2015年3月收治的临床诊断为异位妊娠可保守治疗的患者共108例，治疗方式采用甲氨蝶呤单次剂量妊娠囊内注射和多次小剂量肌肉注射治疗，按照治疗方式不同分为两组，比较两组患者血清βhCG值的变化,异位妊娠包块缩小的程度，并记录不良反应。结果两组保守治疗成功率的比较差异无统计学意义（69.0%vs 66.0%，P＞0.05）；血βhCG下降率和异位妊娠包块直径变化比较差异无统计学意义（P＞0.05）；单次剂量妊娠囊内注射组不良反应的发生率低于分次剂量组（17.2%vs 30.0%，P<0.05），不良反应以胃肠道反应和白细胞降低为主。结论单次妊娠囊注射甲氨蝶呤治疗异位妊娠的成功率与多次肌肉注射的相同，但是多次小剂量的肌肉注射不良反应较多，因此针对适应药物保守治疗的异位妊娠患者，建议采用单次妊娠囊注射。
目的：探討甲氨蝶呤（Methotrexate MTX）保守治療採用不同的治療方案對異位妊娠治療結跼的影響。方法選取我院2010年1月～2015年3月收治的臨床診斷為異位妊娠可保守治療的患者共108例，治療方式採用甲氨蝶呤單次劑量妊娠囊內註射和多次小劑量肌肉註射治療，按照治療方式不同分為兩組，比較兩組患者血清βhCG值的變化,異位妊娠包塊縮小的程度，併記錄不良反應。結果兩組保守治療成功率的比較差異無統計學意義（69.0%vs 66.0%，P＞0.05）；血βhCG下降率和異位妊娠包塊直徑變化比較差異無統計學意義（P＞0.05）；單次劑量妊娠囊內註射組不良反應的髮生率低于分次劑量組（17.2%vs 30.0%，P<0.05），不良反應以胃腸道反應和白細胞降低為主。結論單次妊娠囊註射甲氨蝶呤治療異位妊娠的成功率與多次肌肉註射的相同，但是多次小劑量的肌肉註射不良反應較多，因此針對適應藥物保守治療的異位妊娠患者，建議採用單次妊娠囊註射。
목적：탐토갑안접령（Methotrexate MTX）보수치료채용불동적치료방안대이위임신치료결국적영향。방법선취아원2010년1월～2015년3월수치적림상진단위이위임신가보수치료적환자공108례，치료방식채용갑안접령단차제량임신낭내주사화다차소제량기육주사치료，안조치료방식불동분위량조，비교량조환자혈청βhCG치적변화,이위임신포괴축소적정도，병기록불량반응。결과량조보수치료성공솔적비교차이무통계학의의（69.0%vs 66.0%，P＞0.05）；혈βhCG하강솔화이위임신포괴직경변화비교차이무통계학의의（P＞0.05）；단차제량임신낭내주사조불량반응적발생솔저우분차제량조（17.2%vs 30.0%，P<0.05），불량반응이위장도반응화백세포강저위주。결론단차임신낭주사갑안접령치료이위임신적성공솔여다차기육주사적상동，단시다차소제량적기육주사불량반응교다，인차침대괄응약물보수치료적이위임신환자，건의채용단차임신낭주사。
Objective To study the influence on ectopic pregnancy cure rate when the different methotrexate conservative therapy method were used in ectopic pregnancy. Methods 108 cases from January 2010 to March 2015 who were all diagnosied with ectopic pregnancy in our hospital and could be treated using conservative therapy were Selected. All cases were divided randomly into two groups, one group were treated using a single gestational sac injection and the other one were treated using multiple intramuscular injection in small doses. Then , cure rate, changes of serum beta hCG, decreasing extent of the ectopic pregnancy, and adverse effects were all compared between two groups. Results There was no statistically significant difference between the two groups (69.0%vs 66.0%, P>0.05);And there was no statistical significance differences between blood beta hCG decline rate and blot size change after ectopic pregnancy treatment (P>0.05);Incidence of adverse effects in the single dose group was lower than that in the multiple doses group (17.2%vs 30.0%, P<0.05) and also adverse effects was mainly gastrointestinal reaction and leucocyte decrease. Conclusion The cure rate between two groups was the same, but adverse effects in multiple doses group is more obvious. so a single gestational sac injection was recommended when conservative therapy was used in ectopic pregnancy patients.
