CAJ | 학술논문

表观遗传学近年来备受关注，它主要是指在细胞表型中不依赖于DNA序列改变所产生的可遗传改变。研究已证实，在肿瘤的发生发展中，表观遗传学改变也起到关键作用，尤其是抗癌基因的DNA甲基化、组蛋白乙酰化修饰以及部分抗癌microRNA的失调等表观遗传学改变在肿瘤演进中意义重大。在深入研究这些机制的同时，抗肿瘤治疗的转化研究也逐渐开展并取得了一定成效。本文将从DNA甲基化、组蛋白乙酰化修饰和microRNA调控等方面阐述表观遗传学在抗肿瘤研究中的具体机制，以及由此开展的转化医学研究等内容进行综述。
표관유전학근년래비수관주，타주요시지재세포표형중불의뢰우DNA서렬개변소산생적가유전개변。연구이증실，재종류적발생발전중，표관유전학개변야기도관건작용，우기시항암기인적DNA갑기화、조단백을선화수식이급부분항암microRNA적실조등표관유전학개변재종류연진중의의중대。재심입연구저사궤제적동시，항종류치료적전화연구야축점개전병취득료일정성효。본문장종DNA갑기화、조단백을선화수식화microRNA조공등방면천술표관유전학재항종류연구중적구체궤제，이급유차개전적전화의학연구등내용진행종술。
Recently,epigenetic has been concerned more and more. The epigenetic mainly refers to the genetic alter-ation,but not depends on DNA sequence. Some studies have found that in the progress of tumorigenesis the epigenetic has played some significant roles including anti-cancer gene DNA methylation,histone acetylation and some anti-cancer microRNAs imbalance. While these mechanisms are studied,the transformation studies of anti-cancer therapy are gradually carried out and achieved some results. This article will review from DNA methylation,histone acetylation and microRNA regulation the specific epigenetic mechanisms and translational medicine research of anti-cancer.