CAJ | 학술논문

结合均匀设计（UD）与支持向量回归（SVR）发展了一种新的配方优化方法 UD-SVR。对初始方案预处理后，基于 UD 设计较少试验处理的配方组，并依 SVR 实施核函数寻优、非线性筛选因子和预测，对大于设定阈值的组合进行频次统计寻优，再判断各因子是否外推，确定外推范围后进行下一轮均匀设计，直至获得满意配方。以 UD-SVR 优化链霉菌 H-003菌株发酵培养基，仅通过3轮20个处理，目标值 OD560即由1．72提高至2．22。UD-SVR 有望在多因素多水平配方优化中得到广泛应用。
결합균균설계（UD）여지지향량회귀（SVR）발전료일충신적배방우화방법 UD-SVR。대초시방안예처리후，기우 UD 설계교소시험처리적배방조，병의 SVR 실시핵함수심우、비선성사선인자화예측，대대우설정역치적조합진행빈차통계심우，재판단각인자시부외추，학정외추범위후진행하일륜균균설계，직지획득만의배방。이 UD-SVR 우화련매균 H-003균주발효배양기，부통과3륜20개처리，목표치 OD560즉유1．72제고지2．22。UD-SVR 유망재다인소다수평배방우화중득도엄범응용。
To optimize the fermentation medium of microbial,a novel culture medium optimization method based on uniform de-sign (UD)and support vector regression (SVR)is proposed.Firstly,a composition with fewer schemes is designed by UD meth-od according to the primal formula,and then the prediction based on SVR is carried out after kernel optimization and descriptors screening.The results which have predicted values higher than threshold are analyzed by factor’s frequency statistics.The opti-mization process is iterated to obtain the target result.This method is judged by optimizing the fermentation medium of strepto-mycin H-003 and the OD560 value is increased from 1.72 to 2.22 after 20 schemes.Results show that the novel method is efficient and has the potential in optimizing the complex medium.