中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2015年
8期
869-874
,共6页
李星慧%王建业%徐勇%杨阔%朱小泉%原慧萍%唐雷%孙亮%杨帆
李星慧%王建業%徐勇%楊闊%硃小泉%原慧萍%唐雷%孫亮%楊帆
리성혜%왕건업%서용%양활%주소천%원혜평%당뢰%손량%양범
前列腺肿瘤%多态性,单核苷酸%危险性评估
前列腺腫瘤%多態性,單覈苷痠%危險性評估
전렬선종류%다태성,단핵감산%위험성평고
Prostate neoplasms%Polymorphism,single nucleotide%Risk assessment
目的 探讨8q24 region2单核苷酸多态性(SNP)基因(rs1016343,T)、(rs13252298,G)和(rs6983561,C)与前列腺癌(PCa)患病发病风险的关联,分析这些基因型与PCa患者临床特征的关系. 方法 采用病例对照研究设计,比较病例组(289例)PCa患者和对照组(288例)健康人的等位基因和基因型频率的差异,并探讨各基因变异与患者的确诊年龄、体质指数、Gleason评分、前列腺特异性抗原水平、肿瘤分期等临床特征间的关系. 结果 病例组和对照组rs6983561的CC基因型频率分布比较,差异有统计学意义(OR=1.91,P=0.044).不同年龄的PCa患者中,rs1016343的CC+TC基因型分布频率差异有统计学意义(P=0.000).不同肿瘤分期、进展期和体质指数的PCa患者rs6983561的CC/AC+ AA基因型的分布频率差异有统计学意义(P=0.046;P=0.034;P=0.021).对rs1016343和rs6983561风险基因型进行累积效应分析结果显示,当PCa患者携带0、1、2、≥3个风险基因型时,发生PCa的风险将分别为对照组的1.332、1.416和1.519倍. 结论 染色体8q24 region2 SNP(rs6982561,C)可能与中国北方人PCa患病风险和肿瘤分期、进展期和体质指数有关,8q24基因(rs1016343,T)的年龄可能与PCa的患病风险有关.
目的 探討8q24 region2單覈苷痠多態性(SNP)基因(rs1016343,T)、(rs13252298,G)和(rs6983561,C)與前列腺癌(PCa)患病髮病風險的關聯,分析這些基因型與PCa患者臨床特徵的關繫. 方法 採用病例對照研究設計,比較病例組(289例)PCa患者和對照組(288例)健康人的等位基因和基因型頻率的差異,併探討各基因變異與患者的確診年齡、體質指數、Gleason評分、前列腺特異性抗原水平、腫瘤分期等臨床特徵間的關繫. 結果 病例組和對照組rs6983561的CC基因型頻率分佈比較,差異有統計學意義(OR=1.91,P=0.044).不同年齡的PCa患者中,rs1016343的CC+TC基因型分佈頻率差異有統計學意義(P=0.000).不同腫瘤分期、進展期和體質指數的PCa患者rs6983561的CC/AC+ AA基因型的分佈頻率差異有統計學意義(P=0.046;P=0.034;P=0.021).對rs1016343和rs6983561風險基因型進行纍積效應分析結果顯示,噹PCa患者攜帶0、1、2、≥3箇風險基因型時,髮生PCa的風險將分彆為對照組的1.332、1.416和1.519倍. 結論 染色體8q24 region2 SNP(rs6982561,C)可能與中國北方人PCa患病風險和腫瘤分期、進展期和體質指數有關,8q24基因(rs1016343,T)的年齡可能與PCa的患病風險有關.
목적 탐토8q24 region2단핵감산다태성(SNP)기인(rs1016343,T)、(rs13252298,G)화(rs6983561,C)여전렬선암(PCa)환병발병풍험적관련,분석저사기인형여PCa환자림상특정적관계. 방법 채용병례대조연구설계,비교병례조(289례)PCa환자화대조조(288례)건강인적등위기인화기인형빈솔적차이,병탐토각기인변이여환자적학진년령、체질지수、Gleason평분、전렬선특이성항원수평、종류분기등림상특정간적관계. 결과 병례조화대조조rs6983561적CC기인형빈솔분포비교,차이유통계학의의(OR=1.91,P=0.044).불동년령적PCa환자중,rs1016343적CC+TC기인형분포빈솔차이유통계학의의(P=0.000).불동종류분기、진전기화체질지수적PCa환자rs6983561적CC/AC+ AA기인형적분포빈솔차이유통계학의의(P=0.046;P=0.034;P=0.021).대rs1016343화rs6983561풍험기인형진행루적효응분석결과현시,당PCa환자휴대0、1、2、≥3개풍험기인형시,발생PCa적풍험장분별위대조조적1.332、1.416화1.519배. 결론 염색체8q24 region2 SNP(rs6982561,C)가능여중국북방인PCa환병풍험화종류분기、진전기화체질지수유관,8q24기인(rs1016343,T)적년령가능여PCa적환병풍험유관.
Objective To explore the association between the single nucleotide polymorphism (SNP) of 8q24(rs1016343,T,rs13252298,G and rs6983561,C)genes and prostate cancer (Pca) in Chinese population in Beijing,and to analyze the relationship between these genotypes and clinical characteristics in patients with prostate cancer.Methods Based on a case control study,289 patients with prostate cancer and 288 age-matched control subjects were recruited.The differences of allele and genotype frequencies of 8q24(rs1016343,rs13252298 and rs6983561) genes were analyzed between the two groups and the relationships between different genotypes and clinical features such as age,body mass index (BMI),Gleason score,prostate specific antigen (PSA) level and tumor stage were investigated.Results There was significant difference in the frequency distribution of CC genotype of SNP rs6983561 between case and control groups(OR=1.91,P-0.044).The frequency distribution of CC+TC genotypes of SNPrs1016343 had significant differences among the PCa patients with different ages (P =0.00).The frequency distribution of CC/AC+AA genotypes of SNP rs6983561 had significant differences among the PCa patients with different tumor stage,progressive type and BMI (P=0.046,0.034 and 0.021).The cumulative effects test of risk alleles (rs1016343 and rs6983561) showed that the risk of PCa in patients carrying 1,2,≥3 risk alleles was respectively 1.332,1.416 and 1.519 folds more than that in controls.Conclusions The risk allele C of rs6982561 may be associated with the risk of Pca,tumor stage,progressive type and BMI in people in north China,and age may be correlated with the risk of PCa in people carrying risk allele T of rs1016343.
