CAJ | 학술논문

目的:探讨乌司它丁对于老年食管癌患者术后认知功能障碍的影响.方法:60例静吸复合全麻下行食管癌根治手术患者,随机分为乌司他丁组(U组)和对照组(C组),每组30例.治疗后评估患者手术前、后认知功能.测定血浆白介素-6(IL-6)水平,计算出呼吸指数( R I ).结果:两组患者手术开始后各时间点的I L-6水平和R I均显著高于麻醉诱导前(P<0.05),且C组显著高于U组(P<0.05).结论:乌司他丁可抑制食管癌根治手术患者围术期炎症因子的释放,改善氧供,降低术后认知功能障碍发生率.
목적:탐토오사타정대우노년식관암환자술후인지공능장애적영향.방법:60례정흡복합전마하행식관암근치수술환자,수궤분위오사타정조(U조)화대조조(C조),매조30례.치료후평고환자수술전、후인지공능.측정혈장백개소-6(IL-6)수평,계산출호흡지수( R I ).결과:량조환자수술개시후각시간점적I L-6수평화R I균현저고우마취유도전(P<0.05),차C조현저고우U조(P<0.05).결론:오사타정가억제식관암근치수술환자위술기염증인자적석방,개선양공,강저술후인지공능장애발생솔.
Objective To evaluate the effects of ulinastatin on postoperative cognitive function of elderly patients undergoing esophageal carcinoma radical operation.Methods 60 patients undergone esophageal carcinoma radical operation were randomly divided into ulinastatin group(group U), and control group(group C), 30 cases in each group. The cognitive function was assessed before and after operation, and the levels of serum IL-6 were detected, Respiratory Index(RI) was calculated at the same time.Results The levels of IL-6 and RI in both groups significantly increased after operation, adn group U were significantly higher than that control (P<0.05).Conclusion Ulinastatin can effectively inhibit the release of the inflammatory cytokines and improve oxygen supply, decreasing the postoperative cognitive dysfunction