CAJ | 학술논문

目的:探讨液基细胞学联合沉渣包埋切片及免疫组化检测在胸水诊断中的应用价值.方法:对368例胸水进行液基细胞学检测,其中65例恶性及可疑恶性胸水进行沉渣包埋切片,并联合应用免疫组化染色,进一步明确诊断及追溯其组织来源.结果:65例胸水液基细胞学检测阳性49例(75.38%),可疑阳性16例,经沉渣包埋切片及免疫组化检测出阳性61例,阳性率93.85%,差异有统计学意义(P<0.05);经免疫组化标记结果证实,肺腺癌41例、肺鳞癌2例、肺神经内分泌癌1例、恶性间皮瘤2例、胃肠道癌9例、乳腺癌2例、胆管癌1例、卵巢癌3例、反应性间皮增生4例.结论:液基细胞学联合沉渣包埋切片及免疫组化检测,可提高胸水细胞学诊断准确性和阳性检出率, 并对判断肿瘤细胞组织来源具有临床应用价值.
목적:탐토액기세포학연합침사포매절편급면역조화검측재흉수진단중적응용개치.방법:대368례흉수진행액기세포학검측,기중65례악성급가의악성흉수진행침사포매절편,병연합응용면역조화염색,진일보명학진단급추소기조직래원.결과:65례흉수액기세포학검측양성49례(75.38%),가의양성16례,경침사포매절편급면역조화검측출양성61례,양성솔93.85%,차이유통계학의의(P<0.05);경면역조화표기결과증실,폐선암41례、폐린암2례、폐신경내분비암1례、악성간피류2례、위장도암9례、유선암2례、담관암1례、란소암3례、반응성간피증생4례.결론:액기세포학연합침사포매절편급면역조화검측,가제고흉수세포학진단준학성화양성검출솔, 병대판단종류세포조직래원구유림상응용개치.
Objective To explore the application value of Liquid based cytology combine with sediment embedding biopsy and immunohistochemical detection in the diagnosis of hydrothorax.MethodsTo detecte liquid based cytology of 368 cases of hydrothorax and we found that 65 cases were malignant or suspicious malignant,and we further diagnosis and trace their organization sources by the means of sediment embedding biopsy combined with immunohistochemical staining.Results By the method of liquid based cytology ,we found that 49 cases (75.38%) were positive and 16 cases were suspicious positive . On the other hand ,by the method of sediment embedding biopsy conbined with immunohistochemical detection , 61 cases were positive,with the positive rate of 93.85%,and the difference was statistically significant (p < 0.05). Immunohistochemical markers results Confirmed that 41 cases of patients were lung adenocarcinoma, 2 cases were lung squamous carcinoma,1case was pulmonary neuroendocrine carcinoma, 2 cases were malignant mesothelioma, 9 cases were gastrointestinal carcinoma, 2 cases were breast cancer ,1 case was bile duct carcinoma , 3 cases were ovarian cancer and 4 cases were reactive mesothelium hyperplasia.Conclusion By using Liquid based cytology combined with sediment embedding biopsy and immunohistochemical detection can improve the accuracy of hydrothorax cytology diagnosis and positive detection rate,and be of great clinical application value in estimate the source of tumor cell tissue.