CAJ | 학술논문

目的：分析探讨磁共振成像（M RI）T2值和表观扩散系数（ADC值）用于评价不同程度慢性肝病的临床意义。方法选取经肝穿刺活检确诊的40例肝炎、肝纤维化患者为观察组，另外选取同期来体检的40例健康人作为对照组。两组研究对象通过常规MRI扫描测量 T2值和磁共振弥散加权成像扫描（MR‐DWI）测量肝脏组织ADC值。以肝穿刺病理对照为金标准，对比T2值和ADC值在肝脏纤维化不同分期的变化情况，分析它们之间的相关性。结果对照组和观察组中不同炎症活动分期和纤维化分期、病情轻重的磁共振成像 T2值和ADC值的差异有统计学意义（P＜0．05），观察组中随着炎症活动分期和纤维化分级别的升高和病情的加重，T2值和ADC值相应降低和升高；T2值与病理诊断结果呈明显正相关（P＜0．05），ADC值与病理诊断结果呈明显的负相关（P＜0．05）。结论 MRI T2值和ADC值能够较早评估慢性肝病的纤维化分期和炎症活动度，为临床提供无创、快捷、准确的定量诊断方法，可作为慢性肝病抗病毒、抗纤维化药物治疗的辅助评估手段。
목적：분석탐토자공진성상（M RI）T2치화표관확산계수（ADC치）용우평개불동정도만성간병적림상의의。방법선취경간천자활검학진적40례간염、간섬유화환자위관찰조，령외선취동기래체검적40례건강인작위대조조。량조연구대상통과상규MRI소묘측량 T2치화자공진미산가권성상소묘（MR‐DWI）측량간장조직ADC치。이간천자병리대조위금표준，대비T2치화ADC치재간장섬유화불동분기적변화정황，분석타문지간적상관성。결과대조조화관찰조중불동염증활동분기화섬유화분기、병정경중적자공진성상 T2치화ADC치적차이유통계학의의（P＜0．05），관찰조중수착염증활동분기화섬유화분급별적승고화병정적가중，T2치화ADC치상응강저화승고；T2치여병리진단결과정명현정상관（P＜0．05），ADC치여병리진단결과정명현적부상관（P＜0．05）。결론 MRI T2치화ADC치능구교조평고만성간병적섬유화분기화염증활동도，위림상제공무창、쾌첩、준학적정량진단방법，가작위만성간병항병독、항섬유화약물치료적보조평고수단。
Objective To analyze and investigate the clinical significance of the MRI T2 values and apparent diffusion coefficient (ADC) values for evaluating the different degrees of chronic liver disease .Methods 40 patients with hepatitis and liver fibrosis diagnosed by the liver biopsy in our hospital were selected as the observation group and contemporaneous 40 healthy people undergoing the physical examination were selected as the control group .The T2 values in the two groups were measured by the conventional MRI scanning and the live tissue ADC values were measured by the diffusion weighted magnetic resonance imaging scans (MR‐DWI) .The correlation between the T2 values and ADC values was analyzed .Results The T2 values and ADC values in different inflammatory activity sta‐ges ,fibrosis stages and illness severities had statistically significant differences between the observation and the con‐trol group (P<0 .05) ,with the elevation of inflammatory activity stages and fibrosis stages ,and illness deterioration , the T2 values and ADC values in the observation group were correspondingly reduced and increased ;the T2 values were positively correlated with the pathological diagnosis results (P<0 .05) ,while the ADC values were negatively correlated with the pathological diagnosis results (P<0 .05) .Conclusion MRI T2 values and ADC values can early assess the fibrosis staging and inflammatory activity of chronic liver disease ,provides a noninvasive ,fast and accurate quantitative diagnostic method for clinic ,and can serve as an auxiliary assessment means of anti‐virus ,anti fibrosis medication therapy of chronic liver disease .