CAJ | 학술논문

目的：探究宫颈癌不同临床分期患者微循环以及免疫水平。方法选择2012年8月至2014年8月接受治疗的宫颈癌患者73例作为观察组，再选择同期进行健康体检的女性73例作为对照组。对比两组血浆中 T细胞亚群数量，两组NK细胞和 sIgA水平，两组微循环状态，两组血清免疫指标水平。结果观察组CD3＋、CD3＋CD4＋、CD4／CD8、NK、IL‐2、IFN‐γ以及IL‐10平均水平均明显低于对照组，并且从Ⅰ～Ⅳ期呈现下降趋势。而sI‐g A、IL‐4水平高于对照组，从Ⅰ～Ⅳ期呈现上升趋势。另外观察组微循环状态中无聚集的少于对照组，而轻度聚集、中度聚集以及重度聚集的均多于对照组，在Ⅰ期至Ⅳ期中无聚集所占比例逐渐减小，而重度聚集的比例增加，差异均有统计学意义（均 P＜0．05）。结论宫颈癌患者血清中相关免疫水平低于正常水平，其微循环聚集程度更大，并随着宫颈癌程度的加深其免疫水平更低，具有较大的临床指导意义。
목적：탐구궁경암불동림상분기환자미순배이급면역수평。방법선택2012년8월지2014년8월접수치료적궁경암환자73례작위관찰조，재선택동기진행건강체검적녀성73례작위대조조。대비량조혈장중 T세포아군수량，량조NK세포화 sIgA수평，량조미순배상태，량조혈청면역지표수평。결과관찰조CD3＋、CD3＋CD4＋、CD4／CD8、NK、IL‐2、IFN‐γ이급IL‐10평균수평균명현저우대조조，병차종Ⅰ～Ⅳ기정현하강추세。이sI‐g A、IL‐4수평고우대조조，종Ⅰ～Ⅳ기정현상승추세。령외관찰조미순배상태중무취집적소우대조조，이경도취집、중도취집이급중도취집적균다우대조조，재Ⅰ기지Ⅳ기중무취집소점비례축점감소，이중도취집적비례증가，차이균유통계학의의（균 P＜0．05）。결론궁경암환자혈청중상관면역수평저우정상수평，기미순배취집정도경대，병수착궁경암정도적가심기면역수평경저，구유교대적림상지도의의。
Objective To explore the microcirculation and immunity level in the patients with different clinical stages of cervical cancer .Methods 73 cases of cervical cancer treated in our hospital from August 2012 to August 2014 were selected as the observation group ,and contemporaneous 73 healthy women of physical examination were selected as the control group .The plasma levels of T cell subsets ,NK cells and sIgA level ,microcirculation state and serum immune indexes were compared between the two groups .Results CD3+ ,CD3+ CD4+ ,CD4/CD8 ,NK ,IL‐2 , IFN‐gamma and IL‐10 average levels in the observation group were less than those in the control group and showed a downward trend from the stage Ⅰ to Ⅳ .But the sIgA and IL‐4 levels were higher than those in the control group and showed a rising trend from the stageⅠ to Ⅳ .In addition ,non‐aggregation in the microcirculation state in the observa‐tion group was less than that in the control group ,and mild ,moderate and severe aggregation were more than those in the control group ,the non‐aggregation proportion was gradually reduced from the stage Ⅰ to the stage Ⅳ ,while the proportion of severe aggregation was increased ,the differences were statistically significant (P<0 .05) .Conclusion The serum related immune level in the patients with cervical cancer is lower than the normal level ,its microcirculation aggregation degree is greater .With the deepening of the cervical cancer degree ,the immune level is lower ,which has greater clinical guidance significance .