CAJ | 학술논문

目的：探讨甘精胰岛素联合瑞格列奈治疗糖尿病的临床应用效果。方法选择2011年8月至2014年5月收治的96例口服降糖药物治疗效果不佳的2型糖尿病患者作为研究对象，按随机数字表分为试验组和对照组。对照组患者采用诺和灵30R治疗，试验组患者采用甘精胰岛素联合瑞格列奈治疗，比较两组患者血糖、体质量指数（BMI）、糖化血红蛋白（HbA1c）、胰岛素用量、低血糖发生情况和血糖达标时间。结果两组患者治疗后血糖均明显下降，与治疗前比较差异均有统计学意义（P＜0．05）。治疗后试验组患者血糖在早餐后2 h、午餐后2 h和晚餐后2 h均低于对照组患者，差异均有统计学意义（P＜0．05）。试验组患者BMI、胰岛素用量和血糖达标时间均低于对照组患者，而 HbA1c下降水平高于对照组患者，差异均有统计学意义（P＜0．05）。试验组患者低血糖总发生和夜间低血糖发生率均低于对照组患者，差异有统计学意义（χ2＝9．140、7．500，均 P＜0．05）。结论甘精胰岛素联合瑞格列奈治疗糖尿病具有减少胰岛素用量及注射次数、血糖控制效果佳、安全性好的特点，是一种值得推荐的治疗方案。
목적：탐토감정이도소연합서격렬내치료당뇨병적림상응용효과。방법선택2011년8월지2014년5월수치적96례구복강당약물치료효과불가적2형당뇨병환자작위연구대상，안수궤수자표분위시험조화대조조。대조조환자채용낙화령30R치료，시험조환자채용감정이도소연합서격렬내치료，비교량조환자혈당、체질량지수（BMI）、당화혈홍단백（HbA1c）、이도소용량、저혈당발생정황화혈당체표시간。결과량조환자치료후혈당균명현하강，여치료전비교차이균유통계학의의（P＜0．05）。치료후시험조환자혈당재조찬후2 h、오찬후2 h화만찬후2 h균저우대조조환자，차이균유통계학의의（P＜0．05）。시험조환자BMI、이도소용량화혈당체표시간균저우대조조환자，이 HbA1c하강수평고우대조조환자，차이균유통계학의의（P＜0．05）。시험조환자저혈당총발생화야간저혈당발생솔균저우대조조환자，차이유통계학의의（χ2＝9．140、7．500，균 P＜0．05）。결론감정이도소연합서격렬내치료당뇨병구유감소이도소용량급주사차수、혈당공제효과가、안전성호적특점，시일충치득추천적치료방안。
Objective To investigate the clinical effects of insulin glargine combined with repaglinide in the treatment of diabetes .Methods 96 cases of type 2 diabetes mellitus(T2DM ) with poor effect by oral hypoglycemic drugs in our hospital from August 2011 to May 2014 were chosen as the research subjects and divided into the experi‐mental group and the control group according to the random number table method .The control group was treated with novolin 30R and the experimental group adopted the therapy of insulin glargine combined with repaglinide .The blood glucose ,BMI ,HbA1c ,dosage of insulin ,hypoglycemia occurrence situation and time of blood glucose reaching target were compared between the two groups .Results The blood glucose after treatment in the two group were ob‐viously decreased compared with before treatment ,the difference was statistically significant (P<0 .05) .The blood glucose levels at 2h after breakfast ,2 h after lunch and at 2 h after supper in the experimental group were lower than those in the control group ,the differences were statistically significant (P<0 .05) .BMI ,HbA1c ,dosage of insulin and time of blood glucose reaching target in the experimental group were lower than those in the control group ,while the HbA1c level was higher than that in the control group ,the differences had statistical significance (P<0 .05) .The to‐tal incidence rate of hypoglycemia and incidence rate of hypoglycemia at night in the experimental group were lower than those in the control group ,the differences were statistically significant (χ2 =9 .140 ,χ2 =7 .500 ,P<0 .05) .Con‐clusion Insulin glargine combined with repaglinide has the characteristics of less insulin dosage ,better blood glucose control and good safety in treating T2DM ,which is a treatment scheme worthy to be recommended .