检验医学与临床
檢驗醫學與臨床
검험의학여림상
Laboratory Medicine and Clinic
2015年
21期
3204-3206
,共3页
慢性心力衰竭%氨基末端脑钠肽前体%心肌肌钙蛋白T%心功能分级
慢性心力衰竭%氨基末耑腦鈉肽前體%心肌肌鈣蛋白T%心功能分級
만성심력쇠갈%안기말단뇌납태전체%심기기개단백T%심공능분급
chronic heart failure%N-terminal pro-brain natiuretic peptide%cardiac troponin T%cardiac function classification
目的：观察和分析慢性心力衰竭（CHF）患者血清氨基末端脑钠肽前体（NT‐proBNP）及肌钙蛋白 T （cTnT）水平的变化及其意义。方法选取100例CHF患者作为病例组，选取100例健康人作为健康对照组，对两组研究对象血清NT‐proBNP水平和cTnT水平进行检测和比较。结果病例组患者的血清NT‐proBNP和cTnT水平均明显高于健康对照组（t＝22．154、4．817，P＜0．05）；随着患者心功能级别的升高，血清NT‐proBNP和cTnT水平也呈现逐渐上升的趋势，不同心功能患者之间比较的差异均有统计学意义（q＝3．463～26．384，P＜0．05），上述两个指标均与患者的心功能级别呈正相关关系（rs ＝0．756、0．433，P＜0．05）。结论 CHF患者血清 NT‐proB‐NP和cTnT水平的明显升高反映了患者的心肌细胞损伤和心功能损害，与其心功能级别具有相关性，可作为评价患者心功能状态和病情严重程度的辅助指标。
目的：觀察和分析慢性心力衰竭（CHF）患者血清氨基末耑腦鈉肽前體（NT‐proBNP）及肌鈣蛋白 T （cTnT）水平的變化及其意義。方法選取100例CHF患者作為病例組，選取100例健康人作為健康對照組，對兩組研究對象血清NT‐proBNP水平和cTnT水平進行檢測和比較。結果病例組患者的血清NT‐proBNP和cTnT水平均明顯高于健康對照組（t＝22．154、4．817，P＜0．05）；隨著患者心功能級彆的升高，血清NT‐proBNP和cTnT水平也呈現逐漸上升的趨勢，不同心功能患者之間比較的差異均有統計學意義（q＝3．463～26．384，P＜0．05），上述兩箇指標均與患者的心功能級彆呈正相關關繫（rs ＝0．756、0．433，P＜0．05）。結論 CHF患者血清 NT‐proB‐NP和cTnT水平的明顯升高反映瞭患者的心肌細胞損傷和心功能損害，與其心功能級彆具有相關性，可作為評價患者心功能狀態和病情嚴重程度的輔助指標。
목적：관찰화분석만성심력쇠갈（CHF）환자혈청안기말단뇌납태전체（NT‐proBNP）급기개단백 T （cTnT）수평적변화급기의의。방법선취100례CHF환자작위병례조，선취100례건강인작위건강대조조，대량조연구대상혈청NT‐proBNP수평화cTnT수평진행검측화비교。결과병례조환자적혈청NT‐proBNP화cTnT수평균명현고우건강대조조（t＝22．154、4．817，P＜0．05）；수착환자심공능급별적승고，혈청NT‐proBNP화cTnT수평야정현축점상승적추세，불동심공능환자지간비교적차이균유통계학의의（q＝3．463～26．384，P＜0．05），상술량개지표균여환자적심공능급별정정상관관계（rs ＝0．756、0．433，P＜0．05）。결론 CHF환자혈청 NT‐proB‐NP화cTnT수평적명현승고반영료환자적심기세포손상화심공능손해，여기심공능급별구유상관성，가작위평개환자심공능상태화병정엄중정도적보조지표。
Objective To observe and analyze the changes and significance of serum N‐terminal pro‐brain nati‐uretic peptide (NT‐proBNP) and cardiac troponin T (cTnT ) in the patients with chronic heart failure (CHF) .Meth‐ods 100 cases of CHF were selected as the case group and 100 healthy persons were selected as the healthy control group .The serum NT‐proBNP and cTnT levels in the two group were detected and compared .Results The serum NT‐proBNP and cTnT levels in the case group were significantly higher than those in the healthy control group (t=22 .154 ,4 .817 ,P< 0 .05);with the increase of the cardiac function grade ,the serum NT‐proBNP and cTnT levels showed a gradually upward trend and the differences of the indexes among the different cardiac function grades were statistically significant (q=3 .463-26 .384 ,P<0 .05);the above two indexes were positively correlated with the car‐diac function grade(rs =0 .756 ,0 .433 ,P<0 .05) .Conclusion The significant increase of serum NT‐proBNP and cT‐nT levels in the patients with CHF reflect the injury of myocardial cells and the damage of cardiac function ,which are correlated with the cardiac function grade and can be used as the auxiliary indexes for evaluating the heart function status of the patients and the severity of the diseases .
