CAJ | 학술논문

目的：探讨癫痫持续状态(status epilepticus,SE)患儿治疗前后血浆神经肽 Y(neuropeptide Y,NPY)和甘丙肽(galanin,GAL)水平变化及临床意义。方法 SE 患儿42例作为治疗组,40例健康儿童作为对照组。治疗组给予常规治疗并联用丙戊酸钠。治疗组和对照组在治疗前后测定血浆 NPY 和 GAL 水平。结果和对照组比较,治疗组治疗前NPY 和 GAL 水平较低,差异均有统计学意义(P <0.001)；治疗组治疗后,NPY 和 GAL 水平均升高,和对照组比较,差异均有统计学意义(P <0.001)。结论 NPY 和 GAL 具有抗癫痫作用,提示丙戊酸钠可能通过 NPY 和 GAL 起效。
목적：탐토전간지속상태(status epilepticus,SE)환인치료전후혈장신경태 Y(neuropeptide Y,NPY)화감병태(galanin,GAL)수평변화급림상의의。방법 SE 환인42례작위치료조,40례건강인동작위대조조。치료조급여상규치료병련용병무산납。치료조화대조조재치료전후측정혈장 NPY 화 GAL 수평。결과화대조조비교,치료조치료전NPY 화 GAL 수평교저,차이균유통계학의의(P <0.001)；치료조치료후,NPY 화 GAL 수평균승고,화대조조비교,차이균유통계학의의(P <0.001)。결론 NPY 화 GAL 구유항전간작용,제시병무산납가능통과 NPY 화 GAL 기효。
Objective This article studies on changes and clinical significance of neuropeptide Y (NPY) and galanin (GAL)in children with status epilepticus (SE)before and after treatment. Methods Forty-two children with SE were allocated to a treatment group while 40 healthy children as a control group.The treat-ment group was given conventional therapy combined with sodium valproate.All the levels of plasma NPY and GAL were measured before and after treatment for both groups. Results Compared with the control group, the pre - treatment NPY and GAL in the treatment group decreased and there was statistically significant difference (P <0.001).After treatment in the treatment group both the levels of NPY and GAL elevated,and compared with the control group,there was statistically significant difference (P <0.001). Conclusion So-dium valproate might take an effect in the treatment of SE by the way of anti - epileptic effect of NPY and GAL.