CAJ | 학술논문

目的：探讨具有神经内分泌分化（NED）性质贲门癌的临床病理特点。方法回顾性分析汕头大学医学院第一附属医院2007年9月至2014年10月收治的70例贲门癌伴 NED 患者与同期76例不伴 NED贲门癌患者的临床资料，比较两组患者的临床病理特征的差异。结果贲门癌伴 NED 患者突触素（Syn）和嗜铬素 A（CgA）的阳性率分别为43．2％和22．6％。两组患者的临床病理特征比较，肿瘤的分化程度差异有统计学意义（χ2＝4．989，P ＝0．026）。伴 NED 的贲门癌肿块更大、浸润也更明显，但差异无统计学意义。结论免疫组织化学染色对贲门癌伴 NED 的诊断具有重要价值。伴 NED 的贲门癌分化较差。
목적：탐토구유신경내분비분화（NED）성질분문암적림상병리특점。방법회고성분석산두대학의학원제일부속의원2007년9월지2014년10월수치적70례분문암반 NED 환자여동기76례불반 NED분문암환자적림상자료，비교량조환자적림상병리특정적차이。결과분문암반 NED 환자돌촉소（Syn）화기락소 A（CgA）적양성솔분별위43．2％화22．6％。량조환자적림상병리특정비교，종류적분화정도차이유통계학의의（χ2＝4．989，P ＝0．026）。반 NED 적분문암종괴경대、침윤야경명현，단차이무통계학의의。결론면역조직화학염색대분문암반 NED 적진단구유중요개치。반 NED 적분문암분화교차。
Objective To investigate the clinicopathological features of gastric cardia cancer with neuroendo-crine cell differentiation(NED).Methods From September 2007 to October 2014,the clinicopathological features of 70 gastric cardia cancer patients with NED and 76 cases without NED confirmed by surgical pathology specimens and immunohistochemistry (Syn and CgA)in the First Affiliated Hospital of Shantou University Medical College were ret-rospectively analyzed and compared.Results The positive expression rates of synaptophysin(Syn)and chromogranin A(CgA)were 43.2% and 22.6%,respectively.Tumor differentiation was significantly related with NED (χ2 =4.989,P =0.026).Tumors with NED were larger and had deeper invasion,but they were not statistically significant. Conclusion Immunohistochemistry is important to the diagnosis of NED.Gastric cardia cancer with NED has poorer differentiation.