CAJ | 학술논문

目的：评估薯蓣皂苷元对小鼠的亚慢性毒性作用。方法：采用随机数字表法将80只小鼠分为0（对照）、100、200、400 mg·kg-1共4组，每天灌胃1次，连续给药90天，评估薯蓣皂苷元对小鼠的亚慢性毒性作用。观察指标包括小鼠体质量、毛色、饮食、粪便情况等，检测指标包括血常规分析、血液生化检查和病理学检查。结果：与对照组相比，雄性药物组小鼠体质量略减轻。血液学和病理学检查并无明显异常。结论：薯蓣皂苷元亚慢性毒性无可见不良效应剂量水平大于400 mg·kg-1，口服给药较为安全。
목적：평고서여조감원대소서적아만성독성작용。방법：채용수궤수자표법장80지소서분위0（대조）、100、200、400 mg·kg-1공4조，매천관위1차，련속급약90천，평고서여조감원대소서적아만성독성작용。관찰지표포괄소서체질량、모색、음식、분편정황등，검측지표포괄혈상규분석、혈액생화검사화병이학검사。결과：여대조조상비，웅성약물조소서체질량략감경。혈액학화병이학검사병무명현이상。결론：서여조감원아만성독성무가견불량효응제량수평대우400 mg·kg-1，구복급약교위안전。
This study was aimed to evaluate the subchronic toxicity of diosgenin in mice. A total of 80 mice were divided into 4 groups, which were 0 (control), 100, 200, and 400 mg·kg-1 by the random number table. Intragastric administration was given once a day for 90 days in the assessment of subchronic toxicity of diosgenin among mice. The observed indexes contained body weight, fur color, diet, feces, and etc. The detected indexes contained blood routine analysis, blood biochemistry and pathological examination. The results showed that compared with the control group, the body weights of mice in the male medication group were slight reduced. There were no significant hematologic and pathologic abnormalities. It was concluded that the subchronic toxicity of diosgenin with no observed adverse effect dose level was more than 400 mg·kg-1. The oral administration was relatively safe.