CAJ | 학술논문

目的：以中药茯苓为例，建立一种挖掘药物潜在功能的方法，再通过系统论证使之成为确定的新功能，有利于中药应用范围的扩大和临床疗效的提高。方法：利用先前课题组建立的《普济方》数据库管理系统，对中药茯苓跨病种检索，可以得到含茯苓复方在所有疾病的分布情况，再与历代本草学著作和《中华人民共和国药典》（简称《中国药典》）所记载的功能主治相比较，经过统计分析和逻辑判断，并结合现代药理学研究成果和临床疗效评价，从而获取对茯苓传统和潜在功用的整体认识。结果：从历代本草总结出来的茯苓生津止渴、化痰、益智、固涩、止咳、止呕、活血、开胃和安胎的功效，以及古代含茯苓复方治疗虚损、呕吐、中风、消渴、咳嗽、伤寒、痉病等病症，均未被《中国药典》收录。结论：补肾强壮，止咳化痰，降逆止呕，生津止渴，息风止痉和安胎是茯苓的潜在功用，应当引起学术界的重视。
목적：이중약복령위례，건립일충알굴약물잠재공능적방법，재통과계통론증사지성위학정적신공능，유리우중약응용범위적확대화림상료효적제고。방법：이용선전과제조건립적《보제방》수거고관리계통，대중약복령과병충검색，가이득도함복령복방재소유질병적분포정황，재여역대본초학저작화《중화인민공화국약전》（간칭《중국약전》）소기재적공능주치상비교，경과통계분석화라집판단，병결합현대약이학연구성과화림상료효평개，종이획취대복령전통화잠재공용적정체인식。결과：종역대본초총결출래적복령생진지갈、화담、익지、고삽、지해、지구、활혈、개위화안태적공효，이급고대함복령복방치료허손、구토、중풍、소갈、해수、상한、경병등병증，균미피《중국약전》수록。결론：보신강장，지해화담，강역지구，생진지갈，식풍지경화안태시복령적잠재공용，응당인기학술계적중시。
This study took herbal medicinePoria cocosas an example to establish a method to explore the potential function of herbal medicine. And then, the new function was identified through the systematic study. It was able to improve the application range of herbal medicine and the clinical therapeutic effects. The established database management system ofPu-Ji-Fanghad been used for the searching ofPoria cocosin the treatment of different diseases in order to receive the compound prescription containedPoria cocos in different diseases. Then, indications recorded in herbalism literatures through dynasties and thePharmacopoeia of People’s Republic of China(Chinese Pharmacopoeia) were compared. Through statistical analysis and logical judgment, as well as the combination of modern pharmacological research results and clinical therapeutic evaluations, the overall understanding on conventional and potential functions ofPoria cocos were received. The results showed that the functions ofPoria cocos summarized through dynasties contained alleviating thirst, eliminating phlegm, enhancing memory, astringent, relieving cough and vomiting, invigorating blood circulation, promoting appetite and securing fetus, as well as treatment of deficiency, vomiting, stroke, diabetes, cough, cold damage syndrome, convulsion and other syndrome, were not recorded in theChinese Pharmacopoeia. It was concluded that tonifying kidney, relieving cough and phlegm, relieving vomiting, alleviating thirst, expelling wind, relieving convulsion and securing fetus were the potential function ofPoria cocos, which should arouse the attention from the academic community.