CAJ | 학술논문

Lance-Adams综合征，又称为继发于低氧性脑病的意向性或动作性肌阵挛综合征。国内关于治疗Lance-Adams综合征的报道相对较少，我院通过采用地西泮、丙戊酸等抗癫痫药物对1例Lance-Adams综合征患者进行治疗，并观察其临床表现及脑电图情况，以探究Lance-Adams综合征的临床发病特点及治疗方法，提高对Lance-Adams综合征的认识，便以早诊断、及时救治。经过一系列的治疗之后，患者的临床症状得到有效控制，脑电图结果由起初以3~5 Hz的高频兹波、啄波为主，伴有中、高幅尖、棘波以及棘慢综合波逐渐转变为以8~10 Hz有节律的α波为主，尖、棘波以及棘慢综合波消失。本病例的发病过程及体征情况与相关文献基本相符，经过丙戊酸、地西泮等抗癫痫药物治疗后，病情得到有效缓解，生存质量明显提高，说明丙戊酸、地西泮等抗癫痫药物可作为治疗Lance-Adams综合征的一个选择。
Lance-Adams종합정，우칭위계발우저양성뇌병적의향성혹동작성기진련종합정。국내관우치료Lance-Adams종합정적보도상대교소，아원통과채용지서반、병무산등항전간약물대1례Lance-Adams종합정환자진행치료，병관찰기림상표현급뇌전도정황，이탐구Lance-Adams종합정적림상발병특점급치료방법，제고대Lance-Adams종합정적인식，편이조진단、급시구치。경과일계렬적치료지후，환자적림상증상득도유효공제，뇌전도결과유기초이3~5 Hz적고빈자파、탁파위주，반유중、고폭첨、극파이급극만종합파축점전변위이8~10 Hz유절률적α파위주，첨、극파이급극만종합파소실。본병례적발병과정급체정정황여상관문헌기본상부，경과병무산、지서반등항전간약물치료후，병정득도유효완해，생존질량명현제고，설명병무산、지서반등항전간약물가작위치료Lance-Adams종합정적일개선택。
Lance-Adams symptom also called secondary to hypoxic encephalopathy intentionality or action myoclonus syndrome.Domestic reports on treating Lance-Adams syndrome was relatively small.Our hospital treated one patients with Lance-Adams symptom by using antiepileptic drugs liked diazepam and valproic acid.The clinical feature and electroencephalogram situation was observed to explore the clinical feature of Lance-Adams symptom and treatment method.Then enhance the understanding about Lance-Adams symptom,in order to early diagnosis and timely treatment. After a series of treatment,clinical symptoms of patient under control,electroencephalogram results from the initially mainly with 3-5 Hz high-frequency theta and delta waves and with medium and high amplitude,spike wave and spine slow wave gradually transformed into mainly with 8-10 Hz rhythmic alpha pointed, spike wave and spine slow wave disappeared.The disease process and signs of this patient were consistent with the relevant literature.Throuhg treated with diazepam and valproic acid,this patient’s condition effectively alleviated,life quality improved obvious.Diazepam and valproic acid may be a good choice for Lance-Adams symptom.