CAJ | 학술논문

双硫仑样反应又称戒酒硫样反应，是由于应用药物(头孢类)后饮用含有乙醇的饮品(或接触乙醇)导致体内“乙醛蓄积”而产生的中毒反应。本文就临床遇到的1例静脉滴注注射用头孢美唑钠后饮酒致精神异常的双硫仑样反应患者进行探讨，通过分析其发病后的临床表现和治疗过程，并结合相关文献资料，研究双硫仑样反应的发病机制、现场急救及预防措施。最终笔者建议医务人员临床工作中要提高对双硫仑样反应的认知，尤其是在应用头孢菌素类药物时，需严格掌握用药的适应证及注意事项，重视对患者的宣传教育，以此降低该反应的发生率和误诊率。
쌍류륜양반응우칭계주류양반응，시유우응용약물(두포류)후음용함유을순적음품(혹접촉을순)도치체내“을철축적”이산생적중독반응。본문취림상우도적1례정맥적주주사용두포미서납후음주치정신이상적쌍류륜양반응환자진행탐토，통과분석기발병후적림상표현화치료과정，병결합상관문헌자료，연구쌍류륜양반응적발병궤제、현장급구급예방조시。최종필자건의의무인원림상공작중요제고대쌍류륜양반응적인지，우기시재응용두포균소류약물시，수엄격장악용약적괄응증급주의사항，중시대환자적선전교육，이차강저해반응적발생솔화오진솔。
Double sulfur shimron sample reaction also known asdisulfiram -like reaction.As a result of the accumulation of acetaldehyde poisoning reaction in the body, it is due to drinking alcoholic beverages (or alcohol) after application of drugs (cephalosporins).A case of encounter in clinical was drinking after intravenous dripcefmetazole sodium and resulted in disulfiram-like reaction with mental disorder was analyzed.The pathogenesis,on-site aid and prevention measures were understood by observation the clinical manifestation after occurred,treatment process and combined with relative literature data.Suggested that clinical medical staff to improve the cognition to thedisulfiram-like reaction at work,especially in the application of cephalosporin drugs.It needs to strictly grasp the indications and the matters needing attention and pay more attention to the publicity and education of patients,to decrease the incidence rate and misdiagnosis rate of this reaction.