糖尿病新世界
糖尿病新世界
당뇨병신세계
Diabetes New World
2015年
19期
100-102
,共3页
乳腺癌%2型糖尿病%病理特征
乳腺癌%2型糖尿病%病理特徵
유선암%2형당뇨병%병리특정
Breast Cancer%Type 2 diabetes%Pathological features
目的：研究分析乳腺癌合并2型糖尿病的病理特征情况。方法选取2012年10月—2014年10月该中心门诊随访管理的49例乳腺癌合并糖尿病患者作为观察组，再选取同期该中心门诊随访管理的单纯乳腺癌患者49例作为对照组，对所有患者的临床资料进行回顾性分析。结果观察组的年龄、体重指数、空腹血糖、甘油三酯均显著高于对照组，差异有统计学意义（P＜0.05）；观察组高密度脂蛋白胆固醇显著低于对照组，差异有统计学意义（P＜0.05）；观察组的肿瘤大小、PR表达、TNM分期、EGFR表达、P53表达、组织学分级等与对照组相比，差异无统计学意义（P＞0.05）；观察组淋巴结转移率、HER-2表达阳性率和ER 表达阴性率分别为57.14%、61.22%、61.22%，均显著高于对照组的28.57%、36.73%、32.65%，差异有统计学意义（P＜0.05）。结论糖尿病是引发乳腺癌预后不良的独立危险因素，乳腺癌合并2型糖尿病需要给予合理、有效的治疗。
目的：研究分析乳腺癌閤併2型糖尿病的病理特徵情況。方法選取2012年10月—2014年10月該中心門診隨訪管理的49例乳腺癌閤併糖尿病患者作為觀察組，再選取同期該中心門診隨訪管理的單純乳腺癌患者49例作為對照組，對所有患者的臨床資料進行迴顧性分析。結果觀察組的年齡、體重指數、空腹血糖、甘油三酯均顯著高于對照組，差異有統計學意義（P＜0.05）；觀察組高密度脂蛋白膽固醇顯著低于對照組，差異有統計學意義（P＜0.05）；觀察組的腫瘤大小、PR錶達、TNM分期、EGFR錶達、P53錶達、組織學分級等與對照組相比，差異無統計學意義（P＞0.05）；觀察組淋巴結轉移率、HER-2錶達暘性率和ER 錶達陰性率分彆為57.14%、61.22%、61.22%，均顯著高于對照組的28.57%、36.73%、32.65%，差異有統計學意義（P＜0.05）。結論糖尿病是引髮乳腺癌預後不良的獨立危險因素，乳腺癌閤併2型糖尿病需要給予閤理、有效的治療。
목적：연구분석유선암합병2형당뇨병적병리특정정황。방법선취2012년10월—2014년10월해중심문진수방관리적49례유선암합병당뇨병환자작위관찰조，재선취동기해중심문진수방관리적단순유선암환자49례작위대조조，대소유환자적림상자료진행회고성분석。결과관찰조적년령、체중지수、공복혈당、감유삼지균현저고우대조조，차이유통계학의의（P＜0.05）；관찰조고밀도지단백담고순현저저우대조조，차이유통계학의의（P＜0.05）；관찰조적종류대소、PR표체、TNM분기、EGFR표체、P53표체、조직학분급등여대조조상비，차이무통계학의의（P＞0.05）；관찰조림파결전이솔、HER-2표체양성솔화ER 표체음성솔분별위57.14%、61.22%、61.22%，균현저고우대조조적28.57%、36.73%、32.65%，차이유통계학의의（P＜0.05）。결론당뇨병시인발유선암예후불량적독립위험인소，유선암합병2형당뇨병수요급여합리、유효적치료。
Objective To analysis of breast cancer with pathological cases of type 2 diabetes. Methods Select from October 2012 to October 2014 49 cases of breast cancer clinic visit our center management in patients with diabetes as the observa-tion group, then select breast cancer patients in our center over the same period simple outpatient follow-up management of 49 cases as the control group, all patients The clinical data were retrospectively analyzed. Results Age observation group, body mass index, fasting glucose, triglycerides were significantly higher, the difference was significant (P<0.05); observation group of high-density lipoprotein cholesterol was significantly lower than the control group, the difference was significant (P<0.05); tumor size of the observation group, PR expression, TNM stage, EGFR expression, P53 expression, histological grade, etc. compared with the control group, no significant difference (P>0.05);observation group lymph node metastasis, HER-2 posi-tive expression rates and the expression of ER-negative rates were 57.14%, 61.22%, 61.22%, were significantly higher than the 28.57%, 36.73%, 32.65%, the difference was significant (P<0.05). Conclusion Diabetes is an independent risk factor for breast cancer caused by poor prognosis, breast cancer patients with type 2 diabetes need to be given reasonable, effective treatment.
