世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
World Science and Technology-Modernization of Traditional Chinese Medicine
2015年
9期
1906-1910
,共5页
阿尔茨海默病%Aβ%血脑屏障%中药%RAGE%LRP-1
阿爾茨海默病%Aβ%血腦屏障%中藥%RAGE%LRP-1
아이자해묵병%Aβ%혈뇌병장%중약%RAGE%LRP-1
Alzheimer’s disease%Aβ%blood-brain barrier%traditional Chinese medicine%RAGE%LRP-1
阿尔茨海默病发病（Alzheimer’s Disease，AD）主要病理改变是脑组织中β-淀粉样蛋白（β-amyloid Protein，Aβ）的异常堆积所形成的淀粉样老年斑块（Senile Plaques，SP）。血脑屏障(Blood-brain Barrier，BBB)可以调控Aβ脑内的代谢，通过相关的转运体完成Aβ的跨血脑屏障转运。本文主要通过介绍血脑屏障晚期糖基化终产物受体（Receptor for Advanced Glycation End Products，RAGE）及低密度脂蛋白受体相关蛋白-1（Low Density Lipoprotein Receptor-related Protein-1，LRP-1）这两个主要转运体来阐释Aβ的脑内堆积及其产生的炎性因子对神经元毒性的作用机理，由此进一步探讨利用中医药对血脑屏障RAGE与LRP-1两种转运蛋白的调节，减少Aβ脑内的异常沉积、缓解脑内炎症反应，保护脑神经元。
阿爾茨海默病髮病（Alzheimer’s Disease，AD）主要病理改變是腦組織中β-澱粉樣蛋白（β-amyloid Protein，Aβ）的異常堆積所形成的澱粉樣老年斑塊（Senile Plaques，SP）。血腦屏障(Blood-brain Barrier，BBB)可以調控Aβ腦內的代謝，通過相關的轉運體完成Aβ的跨血腦屏障轉運。本文主要通過介紹血腦屏障晚期糖基化終產物受體（Receptor for Advanced Glycation End Products，RAGE）及低密度脂蛋白受體相關蛋白-1（Low Density Lipoprotein Receptor-related Protein-1，LRP-1）這兩箇主要轉運體來闡釋Aβ的腦內堆積及其產生的炎性因子對神經元毒性的作用機理，由此進一步探討利用中醫藥對血腦屏障RAGE與LRP-1兩種轉運蛋白的調節，減少Aβ腦內的異常沉積、緩解腦內炎癥反應，保護腦神經元。
아이자해묵병발병（Alzheimer’s Disease，AD）주요병리개변시뇌조직중β-정분양단백（β-amyloid Protein，Aβ）적이상퇴적소형성적정분양노년반괴（Senile Plaques，SP）。혈뇌병장(Blood-brain Barrier，BBB)가이조공Aβ뇌내적대사，통과상관적전운체완성Aβ적과혈뇌병장전운。본문주요통과개소혈뇌병장만기당기화종산물수체（Receptor for Advanced Glycation End Products，RAGE）급저밀도지단백수체상관단백-1（Low Density Lipoprotein Receptor-related Protein-1，LRP-1）저량개주요전운체래천석Aβ적뇌내퇴적급기산생적염성인자대신경원독성적작용궤리，유차진일보탐토이용중의약대혈뇌병장RAGE여LRP-1량충전운단백적조절，감소Aβ뇌내적이상침적、완해뇌내염증반응，보호뇌신경원。
The main pathological change of Alzheimer’s disease (AD) was the formation of senile plaques (SP) induced by the abnormal accumulation ofβ-amyloid protein (Aβ). Blood-brain barrier (BBB) can regulate the Aβ metabolism in the brain through relevant transporter to complete the across BBB transport. This paper introduced two main transporters, which were the receptor for advanced glycation end products (RAGE) and the low density lipoprotein receptor-related protein-1 (LRP-1) in BBB for the elucidation of neuronal cell toxicity induced by inflammatory factors from Aβ accumulation within the brain. It further explored the regulation on two transport proteins, which were RAGE and LRP-1 in BBB for the reduction of abnormal accumulation of Aβ, relieving of inflammation in the brain, and protection of cerebral neurons by traditional Chinese medicine (TCM).
