北方药学
北方藥學
북방약학
Journal of North Pharmacy
2015年
11期
19-20
,共2页
孟鲁司特%沙美特罗替卡松%支气管哮喘%肺功能
孟魯司特%沙美特囉替卡鬆%支氣管哮喘%肺功能
맹로사특%사미특라체잡송%지기관효천%폐공능
Montelukast%Salmeterol fluticasone%Bronchial asthma%Pulmonary function
目的：分析孟鲁司特联合沙美特罗替卡松治疗儿童支气管哮喘的疗效。方法：以我院2012年4月～2015年4月收治的60例支气管哮喘患儿为研究对象，以随机双盲法将其分为两组，各30例，对照组采取单纯沙美特罗替卡松治疗，观察组在对照组基础上联合孟鲁司特治疗，比较两组临床疗效、临床症状缓解时间及治疗前后肺功能达标情况。结果：观察组总有效率、治疗3个月肺功能达标率分别为96.7%、73.3%，较对照组的80.0%、43.3%差异有统计学意义（P＜0.05）。两组喘息消失时间[（4.6±1.5）VS（5.8±1.3）]d、气促消失时间[（5.3±2.2）VS（6.5±2.3）]d、肺部啰音消失时间[（5.5±2.4）VS（7.8±2.3）]d比较差异有统计学意义（P＜0.05）。结论：孟鲁司特联合沙美特罗替卡松治疗儿童支气管哮喘疗效明确，能明显改善临床症状，促进肺功能恢复，值得临床推广。
目的：分析孟魯司特聯閤沙美特囉替卡鬆治療兒童支氣管哮喘的療效。方法：以我院2012年4月～2015年4月收治的60例支氣管哮喘患兒為研究對象，以隨機雙盲法將其分為兩組，各30例，對照組採取單純沙美特囉替卡鬆治療，觀察組在對照組基礎上聯閤孟魯司特治療，比較兩組臨床療效、臨床癥狀緩解時間及治療前後肺功能達標情況。結果：觀察組總有效率、治療3箇月肺功能達標率分彆為96.7%、73.3%，較對照組的80.0%、43.3%差異有統計學意義（P＜0.05）。兩組喘息消失時間[（4.6±1.5）VS（5.8±1.3）]d、氣促消失時間[（5.3±2.2）VS（6.5±2.3）]d、肺部啰音消失時間[（5.5±2.4）VS（7.8±2.3）]d比較差異有統計學意義（P＜0.05）。結論：孟魯司特聯閤沙美特囉替卡鬆治療兒童支氣管哮喘療效明確，能明顯改善臨床癥狀，促進肺功能恢複，值得臨床推廣。
목적：분석맹로사특연합사미특라체잡송치료인동지기관효천적료효。방법：이아원2012년4월～2015년4월수치적60례지기관효천환인위연구대상，이수궤쌍맹법장기분위량조，각30례，대조조채취단순사미특라체잡송치료，관찰조재대조조기출상연합맹로사특치료，비교량조림상료효、림상증상완해시간급치료전후폐공능체표정황。결과：관찰조총유효솔、치료3개월폐공능체표솔분별위96.7%、73.3%，교대조조적80.0%、43.3%차이유통계학의의（P＜0.05）。량조천식소실시간[（4.6±1.5）VS（5.8±1.3）]d、기촉소실시간[（5.3±2.2）VS（6.5±2.3）]d、폐부라음소실시간[（5.5±2.4）VS（7.8±2.3）]d비교차이유통계학의의（P＜0.05）。결론：맹로사특연합사미특라체잡송치료인동지기관효천료효명학，능명현개선림상증상，촉진폐공능회복，치득림상추엄。
Objective:To analyze the curative effect of montelukast combined with salmeterol fluticasone in the treatment of children bronchial asthma. Methods:60 cases of children with bronchial asthma admitted into the hospital from April 2012 to April 2015 were selected as the research object and were divided into two groups by the randomized double blind methodwith 30 cases in each. The control group were treated with salmeterol fluticasone alone while the observation group were treated with montelukast based on the control group. The clinical efficacy, remission time of clinical symptoms and the status of meeting the standard of lung function before and after the treatment was compared between the two groups. Results:The total effective rate and control rate of lung function after 3 months of treatment in the observation group respectively were 96.7%and 73.3%, compared with 80%and 43.3%in the control group, the differences were statistically significant(P<0.05). The differences in the disappearing time of wheezing [(4.6±1.5) vs(5.8±1.3)]d, shortness of breath [(5.3±2.2) vs(6.5±2.3)]d and pulmonary rales [(5.5±2.4) vs(7.8±2.3)]d were statistically significant(P<0.05). Conclusion:The curative effect of montelukast combined with salmeterol fluticasone in the treatment of children bronchial asthma is definite, which can improve the clinical symptoms and promote the recovery of pulmonary function, worthy of clinical application.
