CAJ | 학술논문

目的：观察西洋参联合降压药物治疗对低舒张压的老年高血压患者血清 E-选择素及可溶性细胞间黏附分子水平的影响，并探讨西洋参治疗该疾病的机制。方法：选取100名65岁以上的经正规降压治疗后血压控制欠佳的低舒张压的老年高血压患者，随机分为2组，其中50例为西洋参组，采用西洋参联合降压药物治疗；另50例为单用药组，采用单纯降压药物治疗作为对比观察。于治疗前后检测患者血液中 sICAM-1和 sE-selectin 水平。结果：治疗后2组收缩压均有所下降，其中西洋参组下降更为明显（P ＜0．05）；治疗后西洋参组舒张压有所回升，且脉压下降显著，明显优于单用药组（P ＜0．01）。治疗前西洋参组 sICAM-1和 sE-selectin 水平与单用药组比较差异无统计学意义；治疗后2组 sICAM-1和 sE-selec-tin 均显著降低，但西洋参组下降更为明显，与单用药组比较差异有统计学意义（P ＜0．01）。结论：西洋参联合降压药物治疗低舒张压的老年高血压疗效确切，并能通过调节黏附分子的表达来抑制炎性反应，从而达到保护和修复血管内皮细胞、抗血管硬化的目的。
목적：관찰서양삼연합강압약물치료대저서장압적노년고혈압환자혈청 E-선택소급가용성세포간점부분자수평적영향，병탐토서양삼치료해질병적궤제。방법：선취100명65세이상적경정규강압치료후혈압공제흠가적저서장압적노년고혈압환자，수궤분위2조，기중50례위서양삼조，채용서양삼연합강압약물치료；령50례위단용약조，채용단순강압약물치료작위대비관찰。우치료전후검측환자혈액중 sICAM-1화 sE-selectin 수평。결과：치료후2조수축압균유소하강，기중서양삼조하강경위명현（P ＜0．05）；치료후서양삼조서장압유소회승，차맥압하강현저，명현우우단용약조（P ＜0．01）。치료전서양삼조 sICAM-1화 sE-selectin 수평여단용약조비교차이무통계학의의；치료후2조 sICAM-1화 sE-selec-tin 균현저강저，단서양삼조하강경위명현，여단용약조비교차이유통계학의의（P ＜0．01）。결론：서양삼연합강압약물치료저서장압적노년고혈압료효학절，병능통과조절점부분자적표체래억제염성반응，종이체도보호화수복혈관내피세포、항혈관경화적목적。
Objective:To observe the effect of American ginseng on the serum E-selectin and soluble ICAM-1 levels in elderly hy-pertensive patients with low diastolic blood pressure.Methods:In the study,100 elderly hypertensive patients after regular anti-hypertensive therapy with low diastolic blood pressure,who were older than 65 years old,were randomized into two groups.The 50 patients in American ginseng group received combination therapy of American ginseng and anti-hypertensive drugs;the 50 patients in single drug group received only anti-hypertensive drugs.The sICAM-1 and sE-selectin levels in the patients’blood were meas-ured before and after the treatment.Results:The systolic blood pressures in the two groups were reduced after treatment.The A-merican ginseng group showed a greater reduction than the single drug group (P <0.05).The diastolic blood pressures were sig-nificantly increased,and pulse pressures were significantly reduced after the treatment in the American ginseng group,which was superior to the single drug group (P <0.01).There was no significant difference in the sICAM-1 and sE-selectin levels between the American ginseng group and the single drug group before the treatment.The sICAM-1 and sE-selectin levels were effectively reduced in the two groups after the treatment,but the American ginseng group showed a greater reduction in the sICAM-1 and sE-selectin levels than the single drug group (P <0.01).Conclusion:The combination therapy of American ginseng and anti-hyper-tensive drug can effectively treat elderly hypertensive patients with low diastolic blood pressure.It can protect and repair vascular endothelial cells through regulation of adhesion molecules expression and inhibition of inflammatory reaction.