世界中医药
世界中醫藥
세계중의약
World Chinese Medicine
2015年
10期
1525-1528
,共4页
慢性盆腔炎%五味消毒饮%灌肠%TNF -α
慢性盆腔炎%五味消毒飲%灌腸%TNF -α
만성분강염%오미소독음%관장%TNF -α
Chronic pelvic inflammation%Wuwei Xiaodu decoction%Enema%TNF-alpha
目的：观察五味消毒饮灌肠治疗慢性盆腔炎的临床疗效及部分机制。方法：将本院70例慢性盆腔炎随机分为对照组和治疗组，各35例，其中对照组患者口服甲硝唑片及司帕沙星片，连续服用7 d。治疗组在对照组治疗方案基础上加用五味消毒饮灌肠，连续灌肠7 d。比较2组临床疗效、治疗前后简易 McGill 疼痛评分变化及外周血清 TNF －α的浓度变化。结果：1）经过治疗后对照组临床总有效率为80％，治疗组为91．43％，2组比较具有统计学意义（P ＜0．05）；2）治疗前对照 McGill 疼痛评分比较差异无统计学意义（P ＞0．05），治疗7 d 后分别与各自治疗前比较，对照组和治疗组 P 均＜0．05，组间比较，2组比较 P ＜0．05治疗组改善较对照组明显。3）2组治疗前 TNF －α蛋白表达无明显统计学意义（P ＞0．05）；治疗7 d 后，治疗组的 TNF －α蛋白浓度低于对照组；4）McGill 疼痛评分与 TNF －α存在相关关系（P ＜0．05）。结论：五味消毒饮灌肠可明显改善慢性盆腔炎的临床症状，其治疗机制可能与下调 TNF －α有关。
目的：觀察五味消毒飲灌腸治療慢性盆腔炎的臨床療效及部分機製。方法：將本院70例慢性盆腔炎隨機分為對照組和治療組，各35例，其中對照組患者口服甲硝唑片及司帕沙星片，連續服用7 d。治療組在對照組治療方案基礎上加用五味消毒飲灌腸，連續灌腸7 d。比較2組臨床療效、治療前後簡易 McGill 疼痛評分變化及外週血清 TNF －α的濃度變化。結果：1）經過治療後對照組臨床總有效率為80％，治療組為91．43％，2組比較具有統計學意義（P ＜0．05）；2）治療前對照 McGill 疼痛評分比較差異無統計學意義（P ＞0．05），治療7 d 後分彆與各自治療前比較，對照組和治療組 P 均＜0．05，組間比較，2組比較 P ＜0．05治療組改善較對照組明顯。3）2組治療前 TNF －α蛋白錶達無明顯統計學意義（P ＞0．05）；治療7 d 後，治療組的 TNF －α蛋白濃度低于對照組；4）McGill 疼痛評分與 TNF －α存在相關關繫（P ＜0．05）。結論：五味消毒飲灌腸可明顯改善慢性盆腔炎的臨床癥狀，其治療機製可能與下調 TNF －α有關。
목적：관찰오미소독음관장치료만성분강염적림상료효급부분궤제。방법：장본원70례만성분강염수궤분위대조조화치료조，각35례，기중대조조환자구복갑초서편급사파사성편，련속복용7 d。치료조재대조조치료방안기출상가용오미소독음관장，련속관장7 d。비교2조림상료효、치료전후간역 McGill 동통평분변화급외주혈청 TNF －α적농도변화。결과：1）경과치료후대조조림상총유효솔위80％，치료조위91．43％，2조비교구유통계학의의（P ＜0．05）；2）치료전대조 McGill 동통평분비교차이무통계학의의（P ＞0．05），치료7 d 후분별여각자치료전비교，대조조화치료조 P 균＜0．05，조간비교，2조비교 P ＜0．05치료조개선교대조조명현。3）2조치료전 TNF －α단백표체무명현통계학의의（P ＞0．05）；치료7 d 후，치료조적 TNF －α단백농도저우대조조；4）McGill 동통평분여 TNF －α존재상관관계（P ＜0．05）。결론：오미소독음관장가명현개선만성분강염적림상증상，기치료궤제가능여하조 TNF －α유관。
Objective:To observe the the clinical curative effect and part of the mechanism of Wuwei Xiaodu decoction enema in the treatment of chronic pelvic inflammation.Methods:A total of 70 cases of patients with chronic pelvic inflammatory diseases in our hospital were randomly divided into the control group and the observation group,with 35 cases in each group.Patients in the control group had oral Metronidazole tablets and Sparfloxacin tablets and took continuously for 7 days.The observation group had Wuwei Xiaodu decoction enema on the basis of the treatment of the control group,continuously for 7 days.To compare the clinical curative effect of the two groups,the changes of simple McGill pain scores before and after the treatment,and TNF-alpha concen-tration changes in the peripheral blood.Results:1)After treatment,the clinical total effective rate of the control group was 80%, and the observation group was 91.43%.The comparison between the two groups were of statistically difference(P <0.05);2) Before therapy against McGill pain score comparison difference has no statistical significance (P >0.05),while after 7 days of treatment,in each group,compared with before each treatment,there were statistical difference(P <0.05).Also,the comparison between two groups shows that there are statistical difference,and the improvement after the treatment in the observation group is more obvious.3)TNF-alpha protein expression had no obvious differences between the two groups before the treatment (P >0. 05),while after 7 day’s treatment,TNF-alpha protein concentration of the observation group was lower than the control group;4) The McGill pain scores were correlated with the TNF-alpha (P <0.05).Conclusion:Wuwei Xiaodu decoction enema can obvi-ously relieve the clinical symptoms of chronic pelvic inflammation,and the therapeutic mechanism might be its regulation on TNF-alpha.
