CAJ | 학술논문

目的：探讨采用丹黄祛瘀胶囊联合康妇消炎栓治疗慢性盆腔炎所致的慢性疼痛的临床疗效观察及相关机制进行探讨。方法：选择本院妇科2012年4月至2014年3月收治的120例盆腔炎所致的慢性盆腔疼痛患者为研究对象，采用随机数字表，随机分为2组，每组60例。对照组予康妇消炎栓睡前肛用，1次／d，1枚／次，连用2月；观察组在对照组基础上加用丹黄祛瘀胶囊治疗，口服4粒／次，3次／d，连服10 d 为1个疗程，共服用6个疗程。观察2组的临床疗效，同时观察2组治疗前后血清肿瘤坏死因子（Tumor Necrosis Factor，TNF-α）水平，以及患者宫颈黏液中分泌型免疫球蛋白 A（Secretory Im-munoglobulin A，sIgA）和 TNF-α含量。结果：治疗2个月后，2组患者的症状体征评分均得到下降，差异均具有统计学意义（P ＜0．05），观察组下降得更明显，差异有统计学意义（P ＜0．05）；治疗前后，2组血清 TNF-α水平均得到下降，差异均具有统计学意义（P ＜0．05），观察组下降得更明显，差异均具有统计学意义（P ＜0．05）；治疗前后，2组的宫颈黏液 sIAg 及TNF-α水平均升高，差异均具有统计学意义（P ＜0．05），观察组下降得更明显，差异均具有统计学意义（P ＜0．05）。结论：丹黄祛瘀胶囊联合康妇消炎栓疗法能使慢性盆腔炎患者宫颈黏液中的 sIgA、TNF-α的含量升高，从而提高宫颈黏膜对病原微生物反复上行感染的防御能力；同时，其能降低血清中 TNF-α水平，从而减轻免疫损伤，阻断或抑制慢性盆腔炎患者盆腔纤维组织增生，进一步减轻盆腔炎患者的症状，为临床提供了治疗靶点。
목적：탐토채용단황거어효낭연합강부소염전치료만성분강염소치적만성동통적림상료효관찰급상관궤제진행탐토。방법：선택본원부과2012년4월지2014년3월수치적120례분강염소치적만성분강동통환자위연구대상，채용수궤수자표，수궤분위2조，매조60례。대조조여강부소염전수전항용，1차／d，1매／차，련용2월；관찰조재대조조기출상가용단황거어효낭치료，구복4립／차，3차／d，련복10 d 위1개료정，공복용6개료정。관찰2조적림상료효，동시관찰2조치료전후혈청종류배사인자（Tumor Necrosis Factor，TNF-α）수평，이급환자궁경점액중분비형면역구단백 A（Secretory Im-munoglobulin A，sIgA）화 TNF-α함량。결과：치료2개월후，2조환자적증상체정평분균득도하강，차이균구유통계학의의（P ＜0．05），관찰조하강득경명현，차이유통계학의의（P ＜0．05）；치료전후，2조혈청 TNF-α수평균득도하강，차이균구유통계학의의（P ＜0．05），관찰조하강득경명현，차이균구유통계학의의（P ＜0．05）；치료전후，2조적궁경점액 sIAg 급TNF-α수평균승고，차이균구유통계학의의（P ＜0．05），관찰조하강득경명현，차이균구유통계학의의（P ＜0．05）。결론：단황거어효낭연합강부소염전요법능사만성분강염환자궁경점액중적 sIgA、TNF-α적함량승고，종이제고궁경점막대병원미생물반복상행감염적방어능력；동시，기능강저혈청중 TNF-α수평，종이감경면역손상，조단혹억제만성분강염환자분강섬유조직증생，진일보감경분강염환자적증상，위림상제공료치료파점。
Objective:To explore the effect of Dan Huang Quyu Capsule and Kangfu Xiaoyan Suppository to the chronic pain of PID and the Partial mechanism.Methods:We chose 120 patients,through random number table,who visited our hospital from April 2012 to March 2014 March for chronic pelvic pain caused by pelvic inflammatory disease as object of the study.They were randomly divided into two groups of 60 cases.The control group was given Kangfu Xiaoyan suppository with bedtime for 2 months by 1 time per day,1 tablet per time.Observation group,in addition to the treatment that control group recived,taken Dan Huang Quyu capsule oraly by 4 tablets per time,3 times per day,10 days as one course and taking for 6 courses.Clinical efficacy were observed andserum tumor necrosis factor (TNF-α)levels,the patient’s cervical mucus secretory immunoglobulin A (slgA)and TNF-αcontent were tested.Results:After two months,the two groups of patients with signs and symptoms scores were obtained, and the differences were statistically significant (P <0.05).The observation group decreased more significantly and the difference was statistically significant (P <0.05).After treatment,both groups slAg cervical mucus and TNF-αlevels were decreased and the differences were statistically significant (P <0.05).The observation group decreased more significantly wirh differences of sta-tistically significant (P <0.05).Conclusion:Dan Huang Quyu Capsule combining with Kangfu Xiaoyan Suppository could in-crease content of sIgA and TNF-αin patient’cervical mucus is increased,thereby ascending infection defense capabilities.At the same time,it can reduce serum levels of TNF-αso that decrease the immune damage.The therapy could block or inhibit pelvic fi-brosisof patients with chronic pelvic inflammatory disease and reduce the symptoms,therefore,it provides target for clinical treat-ment.