CAJ | 학술논문

目的：比对进口和国产两种不同厂家品牌的血凝试剂对实验动物SD大鼠和人血凝四项（ PT、APTT、TT、FIB）检测结果，观察它们之间是否存在差异。方法选用SPF级SD大鼠及人血凝标本，分别用国产和进口两种不同品牌血凝试剂检测PT、APTT、TT及FIB血凝四项指标。结果两种不同品牌血凝试剂对大鼠血凝四项指标检测结果均存在差异，大鼠血凝指标PT、APTT、FIB国产试剂检测结果高于进口试剂（ P ＜0.05）；大鼠血凝指标TT进口试剂检测结果高于国产试剂（P ＜0.05）；而人血凝标本未见明显差异。结论不同厂家品牌的血凝试剂检测SD大鼠血凝四项（ PT、APTT、TT、FIB）结果可存在差异，各实验室应根据需求建立相应的背景数据。
목적：비대진구화국산량충불동엄가품패적혈응시제대실험동물SD대서화인혈응사항（ PT、APTT、TT、FIB）검측결과，관찰타문지간시부존재차이。방법선용SPF급SD대서급인혈응표본，분별용국산화진구량충불동품패혈응시제검측PT、APTT、TT급FIB혈응사항지표。결과량충불동품패혈응시제대대서혈응사항지표검측결과균존재차이，대서혈응지표PT、APTT、FIB국산시제검측결과고우진구시제（ P ＜0.05）；대서혈응지표TT진구시제검측결과고우국산시제（P ＜0.05）；이인혈응표본미견명현차이。결론불동엄가품패적혈응시제검측SD대서혈응사항（ PT、APTT、TT、FIB）결과가존재차이，각실험실응근거수구건립상응적배경수거。
Objective To compare coagulation data measured with domestic produced and imported coagulation testing solutions on SD rat and human by testing prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time(TT), fibrinogen(FIB).Methods Blood samples were obtained from SPF SD rat and human .Domestic produced and imported coagulation testing solutions were applied to test PT , APTT, TT, and FIB.Results Compared to rat data measured with imported coagulation testing solution , data measured with domestic produced coagulation testing solution of PT, APTT, FIB was significantly higher (P<0.05), while, data of TT was statistically lower(P<0.05), and there was no obvious difference in human blood coagulation .Conclusion The data measured with different coagulation testing solution varies on SD rat , so the laboratories are required to establish reference data according to different products .