CAJ | 학술논문

目的：建立科学的大体病理学检查和组织病理学诊断的评分原则、更合理的评分标准以及合理的统计学方法，为保健食品对胃粘膜损伤有辅助保护作用提供更为科学、可行的评价方法。方法通过对大鼠胃黏膜急性损伤酒精模型的全面分析，针对现行方法中评价方法的缺点，根据病变特点及病理学检查的原则和半定量分析方法，以及相应的统计学方法等信息化处理，进行方法学探讨。结果大体病理学检查按照病变所占面积以及在整个胃粘膜所占的比例；组织病理学诊断根据病变累及粘膜层的深度作为判定粘膜受损严重程度的主要依据，其他各种病变作为参考因素。分别分为未见异常（0分）、轻度病变（1分）、中度病变（2分）和重度病变（3分）。统计学方法采用Ridit统计学方法分析病理学半定量的结果。结论从大体病理学、组织病理学的评价方法以及数据处理方法和结果判定等方面，提出了对胃粘膜损伤有辅助保护功能的动物实验相对更为科学、可行的评价方法的建议。
목적：건립과학적대체병이학검사화조직병이학진단적평분원칙、경합리적평분표준이급합리적통계학방법，위보건식품대위점막손상유보조보호작용제공경위과학、가행적평개방법。방법통과대대서위점막급성손상주정모형적전면분석，침대현행방법중평개방법적결점，근거병변특점급병이학검사적원칙화반정량분석방법，이급상응적통계학방법등신식화처리，진행방법학탐토。결과대체병이학검사안조병변소점면적이급재정개위점막소점적비례；조직병이학진단근거병변루급점막층적심도작위판정점막수손엄중정도적주요의거，기타각충병변작위삼고인소。분별분위미견이상（0분）、경도병변（1분）、중도병변（2분）화중도병변（3분）。통계학방법채용Ridit통계학방법분석병이학반정량적결과。결론종대체병이학、조직병이학적평개방법이급수거처리방법화결과판정등방면，제출료대위점막손상유보조보호공능적동물실험상대경위과학、가행적평개방법적건의。
Objective To establish a scientific and practical principle , grading standard and reasonable statistical method for evaluating the protective effect of health food to gastric mucosal injury , based on general pathology and histopathological diagnosis .Methods A methodological study was conducted on rat model of acute gastric mucosa injury induced by alcoholic through comprehensive analysis and comparing shortcomings of the current standard evaluation method, and methods of semi-quantitative analysis and corresponding information statistic processing were based on characteristics of the lesion and principles of pathology .Results Gross pathological evaluation of gastric mucosa lesion was based on the area occupied and proportion in the whole gastric mucosa .Histopathological diagnosis was based on the mucous layer depth of lesion as main determination point and other lesions as reference factors .Grades of lesion were divided into no abnormality (0), mild lesions (1 point), moderate lesions (2 points), and severe lesions (3 points). Ridit statistical method was used for pathological analysis of semi-quantitative results .Conclusion A scientific and feasible evaluation method for the protective effect of health food to gastric mucosal injury was provided from the aspects of gross pathology , histopathological evaluation method , data processing method and result determination .