中华内科杂志
中華內科雜誌
중화내과잡지
Chinese Journal of Internal Medicine
2015年
11期
945-948
,共4页
多发性硬化%复发%季节%纬度%环境因素
多髮性硬化%複髮%季節%緯度%環境因素
다발성경화%복발%계절%위도%배경인소
Multiple sclerosis%Recurrence%Seasons%Latitude%Environmental factors
目的 通过观察多发性硬化(MS)患者发病/复发的季节及纬度分布特点,分析季节及纬度对MS的影响.方法 回顾性分析2002年1月-2012年12月首都医科大学附属北京天坛医院神经内科264例住院MS患者的资料,其中男88例,女176例,发病/复发共453例次.统计4个季节MS复发情况的差异;选取一个维度跨度较小的地区(北京地区)的MS患者,分析各个月份的发病/复发例次与该月份的平均气温、日光照射强度及照射时间的相关性;以北京市纬度范围(39.39°N～41.07°N)的中位数(40.22°N)为分界线,将MS患者分为高纬度组和低纬度组,比较两组的性别分布、发病年龄、病程及复发情况.结果 4个季节中冬季的发病/复发例次最多(134例次),夏季的发病/复发例次最少(97例次).同一纬度(北京地区)患者的发病/复发人数与该地区的平均气温、阳光照射强度呈负相关(r=-0.699,P=0.006;r=-0.623,P=0.015).高纬度组复发率为68.7％(123/179),高于低纬度组的63.0％(51/81),P=0.000;而两组的性别分布、发病年龄、病程的差异均无统计学意义.结论 MS发病/复发有明显的季节分布特征,且与纬度有关.MS发病/复发与患者居住地的气温、阳光照射强度有关.环境因素是MS发病/复发的一个重要诱因,其中阳光照射最为关键.
目的 通過觀察多髮性硬化(MS)患者髮病/複髮的季節及緯度分佈特點,分析季節及緯度對MS的影響.方法 迴顧性分析2002年1月-2012年12月首都醫科大學附屬北京天罈醫院神經內科264例住院MS患者的資料,其中男88例,女176例,髮病/複髮共453例次.統計4箇季節MS複髮情況的差異;選取一箇維度跨度較小的地區(北京地區)的MS患者,分析各箇月份的髮病/複髮例次與該月份的平均氣溫、日光照射彊度及照射時間的相關性;以北京市緯度範圍(39.39°N～41.07°N)的中位數(40.22°N)為分界線,將MS患者分為高緯度組和低緯度組,比較兩組的性彆分佈、髮病年齡、病程及複髮情況.結果 4箇季節中鼕季的髮病/複髮例次最多(134例次),夏季的髮病/複髮例次最少(97例次).同一緯度(北京地區)患者的髮病/複髮人數與該地區的平均氣溫、暘光照射彊度呈負相關(r=-0.699,P=0.006;r=-0.623,P=0.015).高緯度組複髮率為68.7％(123/179),高于低緯度組的63.0％(51/81),P=0.000;而兩組的性彆分佈、髮病年齡、病程的差異均無統計學意義.結論 MS髮病/複髮有明顯的季節分佈特徵,且與緯度有關.MS髮病/複髮與患者居住地的氣溫、暘光照射彊度有關.環境因素是MS髮病/複髮的一箇重要誘因,其中暘光照射最為關鍵.
목적 통과관찰다발성경화(MS)환자발병/복발적계절급위도분포특점,분석계절급위도대MS적영향.방법 회고성분석2002년1월-2012년12월수도의과대학부속북경천단의원신경내과264례주원MS환자적자료,기중남88례,녀176례,발병/복발공453례차.통계4개계절MS복발정황적차이;선취일개유도과도교소적지구(북경지구)적MS환자,분석각개월빈적발병/복발례차여해월빈적평균기온、일광조사강도급조사시간적상관성;이북경시위도범위(39.39°N～41.07°N)적중위수(40.22°N)위분계선,장MS환자분위고위도조화저위도조,비교량조적성별분포、발병년령、병정급복발정황.결과 4개계절중동계적발병/복발례차최다(134례차),하계적발병/복발례차최소(97례차).동일위도(북경지구)환자적발병/복발인수여해지구적평균기온、양광조사강도정부상관(r=-0.699,P=0.006;r=-0.623,P=0.015).고위도조복발솔위68.7％(123/179),고우저위도조적63.0％(51/81),P=0.000;이량조적성별분포、발병년령、병정적차이균무통계학의의.결론 MS발병/복발유명현적계절분포특정,차여위도유관.MS발병/복발여환자거주지적기온、양광조사강도유관.배경인소시MS발병/복발적일개중요유인,기중양광조사최위관건.
Objective To explore the impact of season and latitude on multiple sclerosis by study the onset/relapse season and latitude distribution in multiple sclerosis (MS) patients.Methods A total of 264 MS patients , with 88 males and 176 females, who were hospitalized in Beijing Tiantan Hospital from January 2002 to December 2012, were enrolled in the study and all the clinical data were retrospectively analyzed.The mean age was (33.9 ± 12.3) years old, with the disease duration of (6.3 ±4.5) years and 453 cases of relapse.The recurrence of MS was collected by four seasons, with March to May defined as spring, June to August as summer, September to November as autumn and December to February as winter.MS patients lived in Beijing (39.39° N-41.07° N) were chosen to test the correlation between the incidence/recurrence and monthly mean temperature, sunlight exposure intensity and duration.All the patients were divided into the high latitude group and the low latitude group, taken the latitude median (40.22° N) of Beijing area as the boundary.Gender composition, age of onset, disease duration and recurrence rate were compared between the two groups.Results Most of the onset/ relapse of MS were observed in winter (134 cases), while summer (97 cases) took the least.In the same latitude region (Beijing area), the onset/ relapse of MS was negatively correlated to the mean temperature and sunlight exposure intensity (r =-0.699, P =0.006;r =-0.623, P =0.015).Recurrence was higher in the high latitude group than in the low latitude group [68.7％ (123/179) vs 63.0％ (51/81), P =0.000], while no significant difference was found in gender composition, age of onset and disease duration between the two groups.Conclusion The onset/recurrence of MS has obvious seasonal characteristics.The onset/recurrence of MS is correlated with latitude, temperature and sunlight exposure intensity of the habitation of MS patients.Environmental factors are important cause of the onset/recurrence of MS, with sunshine exposure as the most key factor.
