世界中医药
世界中醫藥
세계중의약
World Chinese Medicine
2015年
10期
1566-1569
,共4页
干黄茶乳剂%牙周炎%治疗
榦黃茶乳劑%牙週炎%治療
간황다유제%아주염%치료
Ganhuangcha Cream%Periodontitis%Treatment
目的:探讨干黄茶乳剂对牙周炎治疗机制。方法:采用随机数字表法将昆明种小白鼠分为4组,每组10只,其中未经任何处理的小鼠作为对照组,采用20%、40%、80%干黄茶乳剂处理的牙周炎模型小鼠分别作为低、中、高浓度组,组间比较牙龈指数(GI)、血清 IgG、牙周组织 BMP2、IGF1、bFGF 阳性表达量的差异。结果:与对照组比较,低、中、高浓度组各个时间点 GI 值、血清 IgG 水平均明显增高,BMP2、IGF1、bFGF 阳性表达量均明显降低,比较差异具有统计学意义(P <0.05),药物处理1、2 h 时,高浓度组 GI 值、血清 IgG 水平最低,低浓度组最高,药物处理4、6 h 时,中浓度组上述指标最低,低浓度组最高,比较差异具有统计学意义(P <0.05),低、高浓度组 GI 值、血清 IgG 水平随着时间的延长而逐渐增加,中浓度组随着时间的延长而逐渐降低。中浓度组 BMP2、IGF1、bFGF 阳性表达量最高,其次为高浓度组,而低浓度组最低,组间比较差异具有统计学意义(P <0.05)。结论:干黄茶乳剂通过发挥抗炎与修复牙周损伤组织,从而有效治疗牙周炎,且与药物浓度具有相关性,40%干黄茶乳剂维持作用4 h 对牙周炎的抗炎效果最佳,有助于指导牙周炎临床治疗。
目的:探討榦黃茶乳劑對牙週炎治療機製。方法:採用隨機數字錶法將昆明種小白鼠分為4組,每組10隻,其中未經任何處理的小鼠作為對照組,採用20%、40%、80%榦黃茶乳劑處理的牙週炎模型小鼠分彆作為低、中、高濃度組,組間比較牙齦指數(GI)、血清 IgG、牙週組織 BMP2、IGF1、bFGF 暘性錶達量的差異。結果:與對照組比較,低、中、高濃度組各箇時間點 GI 值、血清 IgG 水平均明顯增高,BMP2、IGF1、bFGF 暘性錶達量均明顯降低,比較差異具有統計學意義(P <0.05),藥物處理1、2 h 時,高濃度組 GI 值、血清 IgG 水平最低,低濃度組最高,藥物處理4、6 h 時,中濃度組上述指標最低,低濃度組最高,比較差異具有統計學意義(P <0.05),低、高濃度組 GI 值、血清 IgG 水平隨著時間的延長而逐漸增加,中濃度組隨著時間的延長而逐漸降低。中濃度組 BMP2、IGF1、bFGF 暘性錶達量最高,其次為高濃度組,而低濃度組最低,組間比較差異具有統計學意義(P <0.05)。結論:榦黃茶乳劑通過髮揮抗炎與脩複牙週損傷組織,從而有效治療牙週炎,且與藥物濃度具有相關性,40%榦黃茶乳劑維持作用4 h 對牙週炎的抗炎效果最佳,有助于指導牙週炎臨床治療。
목적:탐토간황다유제대아주염치료궤제。방법:채용수궤수자표법장곤명충소백서분위4조,매조10지,기중미경임하처리적소서작위대조조,채용20%、40%、80%간황다유제처리적아주염모형소서분별작위저、중、고농도조,조간비교아간지수(GI)、혈청 IgG、아주조직 BMP2、IGF1、bFGF 양성표체량적차이。결과:여대조조비교,저、중、고농도조각개시간점 GI 치、혈청 IgG 수평균명현증고,BMP2、IGF1、bFGF 양성표체량균명현강저,비교차이구유통계학의의(P <0.05),약물처리1、2 h 시,고농도조 GI 치、혈청 IgG 수평최저,저농도조최고,약물처리4、6 h 시,중농도조상술지표최저,저농도조최고,비교차이구유통계학의의(P <0.05),저、고농도조 GI 치、혈청 IgG 수평수착시간적연장이축점증가,중농도조수착시간적연장이축점강저。중농도조 BMP2、IGF1、bFGF 양성표체량최고,기차위고농도조,이저농도조최저,조간비교차이구유통계학의의(P <0.05)。결론:간황다유제통과발휘항염여수복아주손상조직,종이유효치료아주염,차여약물농도구유상관성,40%간황다유제유지작용4 h 대아주염적항염효과최가,유조우지도아주염림상치료。
Objective:To investigate the mechanism of Ganhuangcha Cream in treating Periodontitis.Methods:The Kunming mice were divided into four groups by random number table,each group has 10 cases.The group given none-treatment was regar-ded as control group,the rest three groups were treated with 20%,40%,80% Ganhuangcha Cream respectively as Low,Medi-um,High concentration group.After the treatment,the positive expressions of gingival index(GI),serum IgG,periodontium BMP2,IGF1,bFGF were compared among groups.Results:Compared with the control group,GI,serum IgG levels of Low,Me-dium,High concentration group significantly increased,the positive expressions of IGF1,BMP2,bFGF were significantly lower, the difference was statistically significant(P <0.05).After treated for 1 to 2h,GI,serum IgG of High concentration group were lowest,Low concentration group were highest.After treated for 4 to 6h,Medium concentration group were lowest;Low concentra-tion group were highest,the difference was statistically significant (P <0.05).GI,serum IgG of Low,High concentration group increased gradually as the treating time prolonged,while the Medium concentration group decreased.The positive expressions of BMP2,IGF1 and bFGF were highest in Medium concentration group,followed by High concentration group,and then the Low concentration group,the difference was statistically significant (P <0.05).Conclusion:Ganhuangcha Cream can treat periodon-titis effectively by anti-inflammation and and repairing periodontium,which is related to concentration of the drug.The treatment effect is the best when treated by 40% Ganhuangcha Cream for 4h.It provides guidance for the clinical treatment of periodontitis.