北方药学
北方藥學
북방약학
Journal of North Pharmacy
2015年
11期
80-80,81
,共2页
咪达那新%二苯乙腈%合成
咪達那新%二苯乙腈%閤成
미체나신%이분을정%합성
Imidafenacin%Diphenylacetonitrile%Synthesis
目的：对咪达那新的合成工艺进行改进。方法：以二苯乙腈为起始原料，经缩合1、缩合2及水解得到目标产物。结果：经三步合成了目标产物，总收率为68%，目标化合物结构经1HNMR和MS确证。结论：本合成方法原料易得，反应条件温和，适合工业化生产。
目的：對咪達那新的閤成工藝進行改進。方法：以二苯乙腈為起始原料，經縮閤1、縮閤2及水解得到目標產物。結果：經三步閤成瞭目標產物，總收率為68%，目標化閤物結構經1HNMR和MS確證。結論：本閤成方法原料易得，反應條件溫和，適閤工業化生產。
목적：대미체나신적합성공예진행개진。방법：이이분을정위기시원료，경축합1、축합2급수해득도목표산물。결과：경삼보합성료목표산물，총수솔위68%，목표화합물결구경1HNMR화MS학증。결론：본합성방법원료역득，반응조건온화，괄합공업화생산。
Objective: To improve the synthesis process of Imidafenacin. Methods: Starting with diphenylacetonitrile, the target compound was prepared through a three-step procedure including condensation 1, condensation 2 and hydrolysis reaction. Results:The target compound was obtained in an overall yield of 68%. The structure of target compound was confirmed by 1HNMR and MS. Conclusion:The optimized process with easily purchased materials, facile reaction conditions and convenient operation procedures promises a scale-up manufacture.
