CAJ | 학술논문

SAMHD1是宿主限制性天然免疫分子，主要在髓系细胞及静息CD4＋T细胞中表达，通过降低胞内dNTP水平限制HIV-1的复制和感染。近来研究发现SAMHD1还能够促进HIV／SIV病毒的基因重组、降解病毒基因组RNA以及抑制病毒在细胞间的传播，在病毒的感染、复制、包装、传播等整个生命过程中都发挥着一定的作用。目前这一天然抗病毒蛋白分子已经成为HIV研究领域的新热点，本文将就SAMHD1抗HIV病毒研究的最新进展做一综述。
SAMHD1시숙주한제성천연면역분자，주요재수계세포급정식CD4＋T세포중표체，통과강저포내dNTP수평한제HIV-1적복제화감염。근래연구발현SAMHD1환능구촉진HIV／SIV병독적기인중조、강해병독기인조RNA이급억제병독재세포간적전파，재병독적감염、복제、포장、전파등정개생명과정중도발휘착일정적작용。목전저일천연항병독단백분자이경성위HIV연구영역적신열점，본문장취SAMHD1항HIV병독연구적최신진전주일종술。
The host protein SAMHD1 has been identified as the first mammalian deoxynucleoside triphosphate triphosphohydrolase (dNTPase), which blocks the infection of HIV-1 in non-cycling immune cells.SAMHD1 protein is highly expressed in human myeloid-lineage cells and resting CD4+T lymphocytes, which restricts HIV-1 replication by hydrolyzing the cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA ( cDNA) synthesis. Recent studies have revealed that SAMHD 1 plays an important role in virus whole life by promoting HIV -1 genome recombination, degenerating viral genome RNA and restricting virus transmission between cells .In this review, these progress on SAMHD1 research are summarized and the mechanisms by which SAMHD 1 mediates retroviral restriction are analyzed .