CAJ | 학술논문

目的：探讨氟伏沙明联合思维阻断疗法对强迫症的疗效。方法采用随机数字表法将56例存在强迫性思维并符合《国际疾病分类（第10版）》（ICD -10）诊断标准的强迫症患者分为氟伏沙明单一治疗组和氟伏沙明联合思维阻断疗法治疗组，观察12周。于治疗前、治疗第4、8、12周末采用耶鲁布朗强迫症状量表（Y - BOCS）进行评定，并采用生活质量综合评定问卷（GQOLI -74）评估治疗前后的生活质量。结果治疗前两组 Y - BOCS 和GQOLI -74评分差异无统计学意义（P >0.05），治疗4周后两组 Y - BOCS 评分较治疗前低，差异有统计学意义（P<0.05），治疗8周后联合组评分较对照组降低更明显，差异有统计学意义（P <0.05）；治疗12周后，联合组 GQOLI-74心理功能和社会功能评分高于对照组（P <0.05）。结论氟伏沙明联合思维阻断疗法治疗有强迫性思维的强迫症患者较单用氟伏沙明疗效更好，并能改善患者的生活质量。
목적：탐토불복사명연합사유조단요법대강박증적료효。방법채용수궤수자표법장56례존재강박성사유병부합《국제질병분류（제10판）》（ICD -10）진단표준적강박증환자분위불복사명단일치료조화불복사명연합사유조단요법치료조，관찰12주。우치료전、치료제4、8、12주말채용야로포랑강박증상량표（Y - BOCS）진행평정，병채용생활질량종합평정문권（GQOLI -74）평고치료전후적생활질량。결과치료전량조 Y - BOCS 화GQOLI -74평분차이무통계학의의（P >0.05），치료4주후량조 Y - BOCS 평분교치료전저，차이유통계학의의（P<0.05），치료8주후연합조평분교대조조강저경명현，차이유통계학의의（P <0.05）；치료12주후，연합조 GQOLI-74심리공능화사회공능평분고우대조조（P <0.05）。결론불복사명연합사유조단요법치료유강박성사유적강박증환자교단용불복사명료효경호，병능개선환자적생활질량。
Objective To observe the clinical efficacy of fluvoxamine combined with thinking prevention therapy on obsessive compulsive disorder. Methods A total of 56 patients with obsessive thinking and obsessive - compulsive disorder confirmed by ICD -10 diagnostic criteria were randomly divided into single fluvoxamine group and fluvoxamine combined with thinking prevention therapy group,and observed for 12 weeks. Yale - Brown Obsessive Compulsive Scale(Y - BOCS)was used to evaluate the mental status of subjects before treatment and the 4th ,8th ,12th week after the treatment. Meanwhile,the life quality of the subjects was evaluated by the Generic Life Quality Inventory(GQOLI - 74)at the same intervals. Results Before treatment,there was no statistically significant difference among Y - BOCS and GQOLI - 74 scores of the two groups(P > 0. 05). 4 weeks after treatment,Y - BOCS scores of the two groups was lower than those of before treatment,the difference was statistically significant(P < 0. 05). 8 weeks after treatment,the Y - BOCS score of the combined group decreased more than the control group,the difference was statistically significant(P < 0. 05). 12 weeks after treatment,the combined group psychological function and social function of GQOLI - 74 score were higher than that of control group(P < 0. 05). Conclusion Fluvoxamine combined with thinking prevention therapy has better efficacy than use fluvoxam-ine for patients with obsessive thinking and obsessive - compulsive disorder,and it can improve the patient′s quality of life.