世界中西医结合杂志
世界中西醫結閤雜誌
세계중서의결합잡지
World Journal of Integrated Traditional and Western Medicine
2015年
10期
1434-1437
,共4页
徐亚萍%刘香环%王海丽%姚宁璐
徐亞萍%劉香環%王海麗%姚寧璐
서아평%류향배%왕해려%요저로
黑升麻提取物%莉芙敏%绝经症状
黑升痳提取物%莉芙敏%絕經癥狀
흑승마제취물%리부민%절경증상
Black cohosh extract%Remiferain%Menopausal syndrome
目的：探讨黑升麻提取物（莉芙敏）治疗绝经相关症状的疗效。方法选取出现绝经相关症状[Kupperman 绝经指数（KMI）≥15分]的妇女90例，按用药意愿分为对照组（不用药组）31例和研究组（莉芙敏组）59例，观察期3个月，评估治疗前后症状评分改变情况及研究组治疗后的有效率。观察莉芙敏对于轻度、中度、重度症状的治疗评分改变情况及有效率。结果研究组服用莉芙敏3个月后，KMI 评分下降（t =14.302，P =0.000）。对照组治疗3个月后 KMI 评分与治疗前比较差异无统计学意义（t =-0.465，P =0.643）。治疗12周后研究组评分明显低于对照组（t =-4.730，P=0.000）。研究组治疗后总有效率为69.5%。研究组内轻度、中度、重度症状者治疗前后评分比较差异有统计学意义（t =0.8061，t =3.873，t =0.6318，P 值均为0.000）。研究组内轻度、中度症状者（81.2%、76.2%）治疗后有效率优于重度症状者（45.5%）（P =0.028、P =0.039），轻、中度症状者之间疗效比较差异无统计学意义（P =0.517）。结论黑升麻提取物（莉芙敏）治疗绝经相关症状有较好的临床疗效，对于轻度及中度症状者能够明显改善其临床症状。
目的：探討黑升痳提取物（莉芙敏）治療絕經相關癥狀的療效。方法選取齣現絕經相關癥狀[Kupperman 絕經指數（KMI）≥15分]的婦女90例，按用藥意願分為對照組（不用藥組）31例和研究組（莉芙敏組）59例，觀察期3箇月，評估治療前後癥狀評分改變情況及研究組治療後的有效率。觀察莉芙敏對于輕度、中度、重度癥狀的治療評分改變情況及有效率。結果研究組服用莉芙敏3箇月後，KMI 評分下降（t =14.302，P =0.000）。對照組治療3箇月後 KMI 評分與治療前比較差異無統計學意義（t =-0.465，P =0.643）。治療12週後研究組評分明顯低于對照組（t =-4.730，P=0.000）。研究組治療後總有效率為69.5%。研究組內輕度、中度、重度癥狀者治療前後評分比較差異有統計學意義（t =0.8061，t =3.873，t =0.6318，P 值均為0.000）。研究組內輕度、中度癥狀者（81.2%、76.2%）治療後有效率優于重度癥狀者（45.5%）（P =0.028、P =0.039），輕、中度癥狀者之間療效比較差異無統計學意義（P =0.517）。結論黑升痳提取物（莉芙敏）治療絕經相關癥狀有較好的臨床療效，對于輕度及中度癥狀者能夠明顯改善其臨床癥狀。
목적：탐토흑승마제취물（리부민）치료절경상관증상적료효。방법선취출현절경상관증상[Kupperman 절경지수（KMI）≥15분]적부녀90례，안용약의원분위대조조（불용약조）31례화연구조（리부민조）59례，관찰기3개월，평고치료전후증상평분개변정황급연구조치료후적유효솔。관찰리부민대우경도、중도、중도증상적치료평분개변정황급유효솔。결과연구조복용리부민3개월후，KMI 평분하강（t =14.302，P =0.000）。대조조치료3개월후 KMI 평분여치료전비교차이무통계학의의（t =-0.465，P =0.643）。치료12주후연구조평분명현저우대조조（t =-4.730，P=0.000）。연구조치료후총유효솔위69.5%。연구조내경도、중도、중도증상자치료전후평분비교차이유통계학의의（t =0.8061，t =3.873，t =0.6318，P 치균위0.000）。연구조내경도、중도증상자（81.2%、76.2%）치료후유효솔우우중도증상자（45.5%）（P =0.028、P =0.039），경、중도증상자지간료효비교차이무통계학의의（P =0.517）。결론흑승마제취물（리부민）치료절경상관증상유교호적림상료효，대우경도급중도증상자능구명현개선기림상증상。
Objective To evaluate the effectiveness of black cohosh extract( Remiferain)for the treatment of menopausal syndrome in women. Methods Ninety women with menopausal syndrome[Kupper-man index( KMI)≥15 points]were recruited and according to their intention,they were assigned into 2 groups to take different kinds of treatment for 3 months. Participants were given Black Cohosh extract daily in research group(Remiferain group),and patients were given nothing in contrast group(No medicine group). Observation period was for 3 months,and the symptom scores change before and after the treatment as well as the efficacy was assessed. The difference between mild,moderate and severe symptoms were observed. Re-sults After 3 months,KMI scores dropped significantly in research group(t = 14. 302,P = 0. 000),and KMI scores had no significant difference in contrast group(t = - 0. 465,P = 0. 643),as well as KMI scores had significant difference between research group and contrast group after 3 months(t = - 4. 730,P = 0. 000). Ef-fective rate in research group was 69. 5% . KMI scores dropped significantly in every team(mild,moderate and severe symptoms teams)of research group(t = 0. 806 1,P = 0. 000;t = 3. 873,P = 0. 000;t = 0. 6318,P= 0. 000). Effective rates of the teams of mild and moderate symptoms are superior to the team of severe symptoms significantly(81. 2% :45. 5% :P = 0. 028;76. 2% :45. 5% :χ2 = 4. 246,P = 0. 039),but there was no difference statistical significance between mild and moderate symptoms team(P = 0. 517). Conclusion Black cohosh extract(Remiferain)is effective for the treatment of menopausal syndrome in women,especially for mild and moderate symptoms.
