CAJ | 학술논문

目的：探讨降钙素原(PCT)对慢性阻塞性肺疾病急性加重(AECOPD)患者应用机械通气治疗的预测价值。方法选取2014年2月~2015年5月入院的126例AECOPD患者,根据患者后续治疗方式将其分为单纯用药组(n=58)和机械通气组(n=68),机械通气组进一步分为无创机械通气组(NIMV组,n=38)及有创机械通气组(IMV组,n=30)。构建ROC曲线,分析降钙素原对AECOPD患者行机械通气的预测价值。结果IMV组的PCT值明显高于NIMV组,且两组均高于单纯用药组,差异有统计学意义(P<0.05或P<0.01)。经ROC曲线分析,PCT预测AECOPD患者应用机械通气治疗的曲线下面积为0.69(P<0.05),区分NIMV及IMV的最佳截断值为0.89 ng/ml。结论 PCT可对AECOPD患者应用机械通气治疗进行预测,并可预测机械通气治疗方式的类型。
목적：탐토강개소원(PCT)대만성조새성폐질병급성가중(AECOPD)환자응용궤계통기치료적예측개치。방법선취2014년2월~2015년5월입원적126례AECOPD환자,근거환자후속치료방식장기분위단순용약조(n=58)화궤계통기조(n=68),궤계통기조진일보분위무창궤계통기조(NIMV조,n=38)급유창궤계통기조(IMV조,n=30)。구건ROC곡선,분석강개소원대AECOPD환자행궤계통기적예측개치。결과IMV조적PCT치명현고우NIMV조,차량조균고우단순용약조,차이유통계학의의(P<0.05혹P<0.01)。경ROC곡선분석,PCT예측AECOPD환자응용궤계통기치료적곡선하면적위0.69(P<0.05),구분NIMV급IMV적최가절단치위0.89 ng/ml。결론 PCT가대AECOPD환자응용궤계통기치료진행예측,병가예측궤계통기치료방식적류형。
Objective To evaluate the predictive value of procalcitonin (PCT)on acute exacerbation chronic obstructive pulmonary diseases (AECOPD) patients with mechanical ventilation. Methods 126 hospitalized patients with AECOPD from February 2014 to May 2015 were selected,and they were divided into simple drug treatment group (n=58)and mechanical ventilation group (n=68) according to the follow-up treatment.Mechanical ventilation group was further divided into noninvasive mechanical ventilation group (NIMV group,n=38) and invasive mechanical ventilation group (IMV group,n=30).The predictive value of PCT on AECOPD patients with mechanical ventilation was evaluated through ROC curve. Results PCT level in AECOPD patients with NIMV group was higher than that in IMV group,and both were higher than that in simple drug treatment group.The difference was statistically significant (P<0.05 or P<0.01). Through ROC curve analysis,the area under curve for PCT predicting AECOPD patients with mechanical ventilation was 0.69(P<0.05).The optimal cutoff value of PCT level for distinguishing NIMV from IMV was 0.89 ng/ml. Conclusion Procalcitonin can be used for predicting mechanical ventilation in patients with AECOPD,and the type of mechanical ventilation as well.