CAJ | 학술논문

目的：探讨七氟醚对小儿室间隔缺损封堵术中应激反应的影响。方法选取2014年6月~2015年3月本院收治的40例先天性心脏病患儿作为研究对象,依据麻醉方法将入选患儿分为七氟醚组和异丙酚组,各20例。七氟醚组给予七氟醚麻醉,异丙酚组给予异丙酚麻醉,比较两组的术中应激反应发生情况。结果七氟醚组T1、T2、T3、T4、T5时的血糖、皮质醇及血浆肾上腺素(E)水平比较,差异无统计学意义(P跃0.05)。异丙酚组T2、T3、T4、T5时的血糖、皮质醇及血浆E水平显著高于T1时,差异有统计学意义(P<0.05)。七氟醚组T1、T2、T3、T4、T5时的MAP、HR及SpO2水平比较,差异无统计学意义(P跃0.05)。异丙酚组T3、T4、T5时的MAP、HR及SpO2水平显著高于T1时,差异有统计学意义(P<0.05)。异丙酚组T2时的MAP、HR水平显著低于T1时,SpO2水平显著高于T1时,差异有统计学意义(P<0.05)。结论七氟醚在小儿室间隔缺损封堵术中具有较小的应激反应,能够更好地维持患儿的循环功能,值得临床推广应用。
목적：탐토칠불미대소인실간격결손봉도술중응격반응적영향。방법선취2014년6월~2015년3월본원수치적40례선천성심장병환인작위연구대상,의거마취방법장입선환인분위칠불미조화이병분조,각20례。칠불미조급여칠불미마취,이병분조급여이병분마취,비교량조적술중응격반응발생정황。결과칠불미조T1、T2、T3、T4、T5시적혈당、피질순급혈장신상선소(E)수평비교,차이무통계학의의(P약0.05)。이병분조T2、T3、T4、T5시적혈당、피질순급혈장E수평현저고우T1시,차이유통계학의의(P<0.05)。칠불미조T1、T2、T3、T4、T5시적MAP、HR급SpO2수평비교,차이무통계학의의(P약0.05)。이병분조T3、T4、T5시적MAP、HR급SpO2수평현저고우T1시,차이유통계학의의(P<0.05)。이병분조T2시적MAP、HR수평현저저우T1시,SpO2수평현저고우T1시,차이유통계학의의(P<0.05)。결론칠불미재소인실간격결손봉도술중구유교소적응격반응,능구경호지유지환인적순배공능,치득림상추엄응용。
Objective To explore the influence of sevoflurane on stress response in children with ventricular septal de-fect occlusion. Methods 40 children with congenital heart disease from June 2014 to March 2015 in our hospital were selected and divided into the sevoflurane group and the propofol group according to the method of anesthesia,20 cases in each group.The sevoflurane group was given sevoflurane anesthesia,the propofol group was given propofol.The intra-operative stress response of two groups was compared. Results There was no significant difference in the level of blood glucose,cortisol and plasma E between T1,T2,T3,T4,T5 in the sevoflurane group (P跃0.05).The level of blood glucose,corti-sol and plasma E at T2,T3,T4,T5 in the propofol group was higher than that at T1,with significant difference (P<0.05). There was no significant difference in the level of MAP,HR and SpO2 between T1,T2,T3,T4,T5 in the sevoflurane group (P>0.05).The level of MAP,HR and SpO2 at T3,T4,T5 in the propofol group was higher than that at T1,with significant dif-ference (P<0.05).The level of MAP,HR at T2 in the propofol group was lower than that at T1,with significant difference (P<0.05).The level of SpO2 at T2 in the propofol group was higher than that at T1,with significant difference (P<0.05). Conclusion Sevoflurane has less stress response in pediatric ventricular septal defect occlusion,which can maintain the stable circulation of children better,it is worthy of clinical promotion and application.