北方药学
北方藥學
북방약학
Journal of North Pharmacy
2015年
11期
95-96,97
,共3页
叶酸%H型高血压%老年患者%血浆同型半胱氨酸%心血管事件
葉痠%H型高血壓%老年患者%血漿同型半胱氨痠%心血管事件
협산%H형고혈압%노년환자%혈장동형반광안산%심혈관사건
Folic acid%H type hypertension%Elderly patients%Homocysteine%Cardiovascular events
目的：探讨叶酸干预治疗对H型老年高血压患者血浆同型半胱氨酸水平和主要心血管事件的影响。方法：将本院2010年1月～2013年1月收治的400例诊断为H型高血压的患者，随机等分为观察组和对照组各200例，对照组给予常规院内降压治疗配合院内健康教育，观察组在对照组治疗基础上加用叶酸，疗程结束后对患者均行1～2年的随访，对两组患者血浆同型半胱氨酸水平及主要心血管事件的发生率进行对比。结果：治疗后观察组血浆同型半胱氨酸水平为（10.1±3.2）μmol/L，明显低于治疗前和对照组水平，差异均有统计学意义（P<0.05）；观察组随访时共发生主要心血管事件14例，发生率为7.0%，明显低于对照组发生率18.0%，差异有统计学意义（P<0.05）。结论：对于H型老年高血压的患者而言，临床治疗中在降压治疗基础上加用叶酸，可有效调节血浆同型半胱氨酸水平，显著减少主要心血管事件。
目的：探討葉痠榦預治療對H型老年高血壓患者血漿同型半胱氨痠水平和主要心血管事件的影響。方法：將本院2010年1月～2013年1月收治的400例診斷為H型高血壓的患者，隨機等分為觀察組和對照組各200例，對照組給予常規院內降壓治療配閤院內健康教育，觀察組在對照組治療基礎上加用葉痠，療程結束後對患者均行1～2年的隨訪，對兩組患者血漿同型半胱氨痠水平及主要心血管事件的髮生率進行對比。結果：治療後觀察組血漿同型半胱氨痠水平為（10.1±3.2）μmol/L，明顯低于治療前和對照組水平，差異均有統計學意義（P<0.05）；觀察組隨訪時共髮生主要心血管事件14例，髮生率為7.0%，明顯低于對照組髮生率18.0%，差異有統計學意義（P<0.05）。結論：對于H型老年高血壓的患者而言，臨床治療中在降壓治療基礎上加用葉痠，可有效調節血漿同型半胱氨痠水平，顯著減少主要心血管事件。
목적：탐토협산간예치료대H형노년고혈압환자혈장동형반광안산수평화주요심혈관사건적영향。방법：장본원2010년1월～2013년1월수치적400례진단위H형고혈압적환자，수궤등분위관찰조화대조조각200례，대조조급여상규원내강압치료배합원내건강교육，관찰조재대조조치료기출상가용협산，료정결속후대환자균행1～2년적수방，대량조환자혈장동형반광안산수평급주요심혈관사건적발생솔진행대비。결과：치료후관찰조혈장동형반광안산수평위（10.1±3.2）μmol/L，명현저우치료전화대조조수평，차이균유통계학의의（P<0.05）；관찰조수방시공발생주요심혈관사건14례，발생솔위7.0%，명현저우대조조발생솔18.0%，차이유통계학의의（P<0.05）。결론：대우H형노년고혈압적환자이언，림상치료중재강압치료기출상가용협산，가유효조절혈장동형반광안산수평，현저감소주요심혈관사건。
Objective: To investigate the effect of folic acid on plasma homocysteine levels and major cardiovascular events in elderly patients with H-type hypertensive. Methods: 400 cases of patients with H-type hypertensive in our hospital from 2010 January to 2013 January were divided randomly into observation group and control group of 200 cases, the control group received routine hospital antihypertensive treatment combined with health education while the observation group used of folic acid on basis of control group, the patients underwent follow-up 1~2 years after treatment. Plasma homocysteine levels and the incidence of major cardiovascular events of the two groups of patients were compared. Results:Plasma homocysteine of the observation group after the treatment was (10.1±3.2)μmol/L, significantly lower than that before treatment and the level of control group, the difference were statistically significant (P<0.05);Incidence rate of major cardiovascular events in observation group during the follow-up was 7.0% of 14cases, significantly lower than 18.0% of the control group, the difference was statistically significant (P<0.05) of two group of comparison. Conclusion: For elderly patients with H type hypertension, the clinical treatment of antihypertensive therapy combined with folic acid can further regulate the plasma homocysteine levels and the incidence of major cardiovascular events which is worthy of clinical application.
