中国基层医药
中國基層醫藥
중국기층의약
Chinese Journal of Primary Medicine and Pharmacy
2015年
21期
3232-3234
,共3页
高效抗逆转录病毒疗法%预防艾滋病母婴传播%干预时间
高效抗逆轉錄病毒療法%預防艾滋病母嬰傳播%榦預時間
고효항역전록병독요법%예방애자병모영전파%간예시간
Highly active anti retroviral therapy%Prevention of mother -to -child transmission%Intervention time
目的：探讨高效抗逆转录病毒疗法（HAART）在预防艾滋病母婴传播（PMTCT）中不同干预时间对阻断效果的影响。方法选择门诊检查并住院分娩的 HIV 阳性妊娠妇女49例，以干预时间孕14周、孕28周、临产为界分三组，A 组20例，B 组19例，C 组10例，对安全分娩的新生儿50例进行18个月的跟踪检测，并分析结果。结果三组抗病毒前艾滋病感染孕产妇的基础免疫状况有可比性（P ＞0．05）。抗病毒后CD ＋4细胞数量变化差异无统计学意义（P ＞0．05）；阻断效果比较：A 组婴儿0感染，B 组1例婴儿感染，C 组2例婴儿感染，A 组和 B 组差异无统计学意义（χ2＝0．97，P ＞0．05），B 组和 C 组差异无统计学意义（χ2＝1.40，P ＞0．05），A 组和 C 组差异有统计学意义（χ2＝4．08，P ＜0．05）。结论HAART 对于阻断 HIV 母婴传播效果非常显著，如果在孕14周开始 HAART，婴儿 HIV 感染率更低，建议及早抗病毒治疗，新生儿分娩后需加强随访和管理。
目的：探討高效抗逆轉錄病毒療法（HAART）在預防艾滋病母嬰傳播（PMTCT）中不同榦預時間對阻斷效果的影響。方法選擇門診檢查併住院分娩的 HIV 暘性妊娠婦女49例，以榦預時間孕14週、孕28週、臨產為界分三組，A 組20例，B 組19例，C 組10例，對安全分娩的新生兒50例進行18箇月的跟蹤檢測，併分析結果。結果三組抗病毒前艾滋病感染孕產婦的基礎免疫狀況有可比性（P ＞0．05）。抗病毒後CD ＋4細胞數量變化差異無統計學意義（P ＞0．05）；阻斷效果比較：A 組嬰兒0感染，B 組1例嬰兒感染，C 組2例嬰兒感染，A 組和 B 組差異無統計學意義（χ2＝0．97，P ＞0．05），B 組和 C 組差異無統計學意義（χ2＝1.40，P ＞0．05），A 組和 C 組差異有統計學意義（χ2＝4．08，P ＜0．05）。結論HAART 對于阻斷 HIV 母嬰傳播效果非常顯著，如果在孕14週開始 HAART，嬰兒 HIV 感染率更低，建議及早抗病毒治療，新生兒分娩後需加彊隨訪和管理。
목적：탐토고효항역전록병독요법（HAART）재예방애자병모영전파（PMTCT）중불동간예시간대조단효과적영향。방법선택문진검사병주원분면적 HIV 양성임신부녀49례，이간예시간잉14주、잉28주、임산위계분삼조，A 조20례，B 조19례，C 조10례，대안전분면적신생인50례진행18개월적근종검측，병분석결과。결과삼조항병독전애자병감염잉산부적기출면역상황유가비성（P ＞0．05）。항병독후CD ＋4세포수량변화차이무통계학의의（P ＞0．05）；조단효과비교：A 조영인0감염，B 조1례영인감염，C 조2례영인감염，A 조화 B 조차이무통계학의의（χ2＝0．97，P ＞0．05），B 조화 C 조차이무통계학의의（χ2＝1.40，P ＞0．05），A 조화 C 조차이유통계학의의（χ2＝4．08，P ＜0．05）。결론HAART 대우조단 HIV 모영전파효과비상현저，여과재잉14주개시 HAART，영인 HIV 감염솔경저，건의급조항병독치료，신생인분면후수가강수방화관리。
Objective To investigate the HAART in PMTCT different intervention time of blocking effect. Methods 49 cases who received out -patient examination and hospital delivery of HIV positive pregnant women were selected,the intervention time pregnant 14 weeks,pregnant 28 weeks.The patients were divided into three groups,group A (n =20),group B (n =19),group C (n =10).The safe delivery,the newborn 50 out of 18 months of tracking and detection,and the results were analyzed.Results Three groups of antiviral HIV infected maternal immune status (P >0.05 ),antiviral CD +4 cell number variation had no statistical significance (P >0.05 ),the blocking effect was A group of infants 0 infection.In group B,1 cases of infant infection.Group C 2 cases of infant infection.Compared between group A and group B,the difference was not statistically significant (χ2 =0.97,P >0.05),compared between group B and group C,the difference was not statistically significant (χ2 =1.40,P >0.05). Compared between group A and group C,the difference had statistical significance (χ2 =4.08,P <0.05 ). Conclusion HAART for blocking HIV mother to child transmission effect is very significant,if in 14 weeks pregnant initiation of HAART,the infant HIV infection rate is lower,recommended the early antiviral treatment and after childbirth to strengthen follow -up and management.
