CAJ | 학술논문

炎症复合体可识别和感受多种微生物产物及细胞内自身代谢性应激而活化胱天蛋白酶，诱导白介素-1β、白介素-18、白介素-33等促炎性反应细胞因子的分泌及多种炎症递质的释放，在抗流感病毒感染过程中发挥着重要作用。这可能为调控流感病毒介导的免疫反应提供新的作用靶点。
염증복합체가식별화감수다충미생물산물급세포내자신대사성응격이활화광천단백매，유도백개소-1β、백개소-18、백개소-33등촉염성반응세포인자적분비급다충염증체질적석방，재항류감병독감염과정중발휘착중요작용。저가능위조공류감병독개도적면역반응제공신적작용파점。
Inflammasome is activated by a diversity of pathogens and endogenous danger signals,which results in Caspase-1 activa-tion and secretion of pro-inflammatory cytokines such as IL-1β,IL-18 and IL-33.The activation of inflammasome has being recog-nized as a key player and potential therapeutic target in fighting influenza virus infections.