CAJ | 학술논문

目的探讨贝那普利、美托洛尔联合治疗老年原发性高血压合并心力衰竭的临床效果. 方法选取80例老年原发性高血压与心力衰竭合并发生患者,均为郑州交通医院2013年5月至2014年5月收治,随机分为两组,每组40例,对照组给予常规方案治疗,观察组加用贝那普利与美托洛尔联合治疗,比较两组患者的临床效果. 结果观察组临床总有效率为95%,明显高于对照组总有效率( 70%) ,差异有统计学意义( P<0.05 ). 治疗前两组患者D0、D1比较差异未见统计学意义(P>0.05),治疗后均有增大,但观察组D1改善幅度高于对照组,差异有统计学意义(P<0.05). 两组治疗前血浆BNP指标及6MWT距离评测比较差异未见统计学意义(P>0.05),治疗后两组血浆BNP均明显下降,6 MWT均延长,且幅度观察组均高于对照组( P<0.05). 结论老年原发性高血压合并心力衰竭的患者,采用贝那普利与美托洛尔联用,可显著改善心功能,提高治疗总有效率,对保障预后有非常积极的临床意义.
목적 탐토패나보리、미탁락이연합치료노년원발성고혈압합병심력쇠갈적림상효과. 방법 선취80례노년원발성고혈압여심력쇠갈합병발생환자,균위정주교통의원2013년5월지2014년5월수치,수궤분위량조,매조40례,대조조급여상규방안치료,관찰조가용패나보리여미탁락이연합치료,비교량조환자적림상효과. 결과 관찰조림상총유효솔위95%,명현고우대조조총유효솔( 70%) ,차이유통계학의의( P<0.05 ). 치료전량조환자D0、D1비교차이미견통계학의의(P>0.05),치료후균유증대,단관찰조D1개선폭도고우대조조,차이유통계학의의(P<0.05). 량조치료전혈장BNP지표급6MWT거리평측비교차이미견통계학의의(P>0.05),치료후량조혈장BNP균명현하강,6 MWT균연장,차폭도관찰조균고우대조조( P<0.05). 결론 노년원발성고혈압합병심력쇠갈적환자,채용패나보리여미탁락이련용,가현저개선심공능,제고치료총유효솔,대보장예후유비상적겁적림상의의.
Objective To investigate the clinical effect of benazepril combined with metoprolol on elderly hyper -tension patients with heart failure .Methods To select 80 cases of essential hypertension elderly patients with heart failure who were treated in traffic hospital of Zhengzhou from May 2013 to May 2014, they were randomly into two groups , with 40 cases in each group .The control group received conventional regimen and the observation group was given benazepril com -bined with metoprolol in addition ,the clinical effects of the two groups were compared .Results The total effective rate in observation group was 95%, which was significantly higher than that in the control group (70%), the difference was signif-icant (P<0.05).D0, D1 had no significant difference between the two groups before treatment (P>0.05), they were increased after treatment , but the improvement of the D 1 was higher in the observation group , the difference was significant (P<0.05).Before treatment, plasma BNP evaluation indicators and 6MWT distance had no significant difference between the two groups (P>0.05), after treatment, plasma BNP were significantly decreased, 6MWT were extended in both groups and the rate in the observation group were higher ( P<0.05 ) .Conclusions Benazepril and metoprolol in treat-ment of elderly patients with essential hypertension and heart failure can significantly improve heart function , increase the total efficiency of the treatment , the prognosis is very positive for the protection of clinical significance .