中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
Chinese Journal of Woman and Child Health Research
2015年
5期
962-963
,共2页
川崎病%雌二醇%睾酮%冠脉损伤
川崎病%雌二醇%睪酮%冠脈損傷
천기병%자이순%고동%관맥손상
Kawasaki disease ( KD)%estradiol ( E2 )%testosterone ( T)%coronary artery damage
目的：监测川崎病患儿外周血雌二醇（ E2）、睾酮（ T）水平的变化，探讨其与川崎病发展及冠脉扩张程度变化的相关性。方法研究选取了2010年至2014年在西安市儿童医院心血管内科确诊的川崎病患儿60名为实验组，实验组又分为冠脉扩张组和无冠脉扩张组；对照组选取同期体检的60名健康儿童测微量元素余存血液进行对比。观察指标为E2、T并与对照组进行比较。结果实验组E2、T含量均低于对照组，差异存在统计学意义（t值分别为2．331、2．812，均P＜0．05）；无冠脉扩张组的E2、T水平均高于冠脉扩张组，差异均具有统计学意义（t值分别为1．512和1．661，均P＜0．05）；实验组E2在男、女性别之间相比，差异无统计学意义（t ＝0．543，P ＞0．05）；实验组 T 在男、女性别之间相比，男性明显低于女性（t ＝1．533，P ＜0．05）。结论 E2、T水平的变化对疾病确诊、发展和转归有较明确的意义，同时对预测川崎病冠脉损伤的发生有一定的预警作用。
目的：鑑測川崎病患兒外週血雌二醇（ E2）、睪酮（ T）水平的變化，探討其與川崎病髮展及冠脈擴張程度變化的相關性。方法研究選取瞭2010年至2014年在西安市兒童醫院心血管內科確診的川崎病患兒60名為實驗組，實驗組又分為冠脈擴張組和無冠脈擴張組；對照組選取同期體檢的60名健康兒童測微量元素餘存血液進行對比。觀察指標為E2、T併與對照組進行比較。結果實驗組E2、T含量均低于對照組，差異存在統計學意義（t值分彆為2．331、2．812，均P＜0．05）；無冠脈擴張組的E2、T水平均高于冠脈擴張組，差異均具有統計學意義（t值分彆為1．512和1．661，均P＜0．05）；實驗組E2在男、女性彆之間相比，差異無統計學意義（t ＝0．543，P ＞0．05）；實驗組 T 在男、女性彆之間相比，男性明顯低于女性（t ＝1．533，P ＜0．05）。結論 E2、T水平的變化對疾病確診、髮展和轉歸有較明確的意義，同時對預測川崎病冠脈損傷的髮生有一定的預警作用。
목적：감측천기병환인외주혈자이순（ E2）、고동（ T）수평적변화，탐토기여천기병발전급관맥확장정도변화적상관성。방법연구선취료2010년지2014년재서안시인동의원심혈관내과학진적천기병환인60명위실험조，실험조우분위관맥확장조화무관맥확장조；대조조선취동기체검적60명건강인동측미량원소여존혈액진행대비。관찰지표위E2、T병여대조조진행비교。결과실험조E2、T함량균저우대조조，차이존재통계학의의（t치분별위2．331、2．812，균P＜0．05）；무관맥확장조적E2、T수평균고우관맥확장조，차이균구유통계학의의（t치분별위1．512화1．661，균P＜0．05）；실험조E2재남、녀성별지간상비，차이무통계학의의（t ＝0．543，P ＞0．05）；실험조 T 재남、녀성별지간상비，남성명현저우녀성（t ＝1．533，P ＜0．05）。결론 E2、T수평적변화대질병학진、발전화전귀유교명학적의의，동시대예측천기병관맥손상적발생유일정적예경작용。
Objective To monitor the changes of estradiol ( E2 ) and testosterone ( T) levels in peripheral blood of Kawasaki disease ( KD) and explore their correlation with the pathogenesis of KD and changes of coronary artery dilation.Methods In cardiovascular department of Xi’an Children’s Hospital 60 children diagnosed with KD were selected for experimental group from 2010 to 2014, and they were divided into coronary artery dilation group and no coronary artery dilation group.Sixty healthy children were selected in control group and the residual blood after examining trace elements were used for comparison.The observation indexes included E2 and T, and results were compared with the control group.Results The levels of E2 and T in the experimental group were lower than those in the control group, and the differences were significant (t value was 2.331 and 2.812, respectively, both P<0.05).Those in no coronary artery dilation group were higher than coronary artery dilation group with significant difference (t value was 1.512 and 1.661, respectively, both P<0.05).In the experimental group E2 level was not remarkably different between males and females (t =0.543,P >0.05), while T level was obviously higher in females than in males (t=1.533,P<0.05).Conclusion The changes of E2 and T levels are important for diagnosis, development and outcomes of disease, and they can be used to predict the occurrence of coronary artery damage in KD.
