中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
Chinese Journal of Woman and Child Health Research
2015年
5期
971-972,1002
,共3页
降钙素原%C-反应蛋白%新生儿感染%预后
降鈣素原%C-反應蛋白%新生兒感染%預後
강개소원%C-반응단백%신생인감염%예후
procalcitonin ( PCT)%C-reactive protein ( CRP)%neonatal infection%prognosis
目的:探讨血清降钙素原( PCT)、C-反应蛋白( CRP)在新生儿感染性疾病中的临床应用及临床价值。方法2014年1月至2014年12月乐清市妇幼保健院收治的120例感染性疾病患儿(47例重症感染伴全身症状新生儿、73例局部感染无全身症状新生儿),以及40例非感染性疾病新生儿,根据细菌培养、血清学检验,将120例感染性疾病患儿分为细菌感染组(76例)、非细菌感染组(44例),检测和比较各组血清PCT、CRP水平。结果与非感染组相比,重症感染组、局部感染组的血清CRP、PCT浓度均明显升高( CRP:t=8.93、t=6.17;PCT:t=7.24、t=5.31;均P<0.05)。与局部感染组相比,重症感染组血清CRP、PCT浓度均明显升高(CRP:t=4.29;PCT:t=5.47;均P<0.05)。与非细菌感染组相比,治疗前细菌感染组血清CRP、PCT浓度均明显升高(CRP:t=8.49;PCT:t=7.14;均P<0.05);与治疗前相比,治疗后细菌感染组血清CRP、PCT浓度明显降低(CRP:t=7.61;PCT:t=6.38;均P<0.05)。与白细胞计数检测相比,CRP、PCT检测的敏感度、特异度均明显增高(CRP:t敏感度=12.90、t特异度=33.97;PCT:t敏感度=20.95、t特异度=50.42;均P<0.05)。结论 CRP、PCT检测为新生儿感染性疾病的早期诊断及预后评估,提供了快速的病原学诊断依据,动态观察感染程度及感染控制情况。
目的:探討血清降鈣素原( PCT)、C-反應蛋白( CRP)在新生兒感染性疾病中的臨床應用及臨床價值。方法2014年1月至2014年12月樂清市婦幼保健院收治的120例感染性疾病患兒(47例重癥感染伴全身癥狀新生兒、73例跼部感染無全身癥狀新生兒),以及40例非感染性疾病新生兒,根據細菌培養、血清學檢驗,將120例感染性疾病患兒分為細菌感染組(76例)、非細菌感染組(44例),檢測和比較各組血清PCT、CRP水平。結果與非感染組相比,重癥感染組、跼部感染組的血清CRP、PCT濃度均明顯升高( CRP:t=8.93、t=6.17;PCT:t=7.24、t=5.31;均P<0.05)。與跼部感染組相比,重癥感染組血清CRP、PCT濃度均明顯升高(CRP:t=4.29;PCT:t=5.47;均P<0.05)。與非細菌感染組相比,治療前細菌感染組血清CRP、PCT濃度均明顯升高(CRP:t=8.49;PCT:t=7.14;均P<0.05);與治療前相比,治療後細菌感染組血清CRP、PCT濃度明顯降低(CRP:t=7.61;PCT:t=6.38;均P<0.05)。與白細胞計數檢測相比,CRP、PCT檢測的敏感度、特異度均明顯增高(CRP:t敏感度=12.90、t特異度=33.97;PCT:t敏感度=20.95、t特異度=50.42;均P<0.05)。結論 CRP、PCT檢測為新生兒感染性疾病的早期診斷及預後評估,提供瞭快速的病原學診斷依據,動態觀察感染程度及感染控製情況。
목적:탐토혈청강개소원( PCT)、C-반응단백( CRP)재신생인감염성질병중적림상응용급림상개치。방법2014년1월지2014년12월악청시부유보건원수치적120례감염성질병환인(47례중증감염반전신증상신생인、73례국부감염무전신증상신생인),이급40례비감염성질병신생인,근거세균배양、혈청학검험,장120례감염성질병환인분위세균감염조(76례)、비세균감염조(44례),검측화비교각조혈청PCT、CRP수평。결과여비감염조상비,중증감염조、국부감염조적혈청CRP、PCT농도균명현승고( CRP:t=8.93、t=6.17;PCT:t=7.24、t=5.31;균P<0.05)。여국부감염조상비,중증감염조혈청CRP、PCT농도균명현승고(CRP:t=4.29;PCT:t=5.47;균P<0.05)。여비세균감염조상비,치료전세균감염조혈청CRP、PCT농도균명현승고(CRP:t=8.49;PCT:t=7.14;균P<0.05);여치료전상비,치료후세균감염조혈청CRP、PCT농도명현강저(CRP:t=7.61;PCT:t=6.38;균P<0.05)。여백세포계수검측상비,CRP、PCT검측적민감도、특이도균명현증고(CRP:t민감도=12.90、t특이도=33.97;PCT:t민감도=20.95、t특이도=50.42;균P<0.05)。결론 CRP、PCT검측위신생인감염성질병적조기진단급예후평고,제공료쾌속적병원학진단의거,동태관찰감염정도급감염공제정황。
Objective To study the clinical application and clinical value of serum procalcitonin ( PCT) and C-reactive protein ( CRP) in neonatal infection.Methods From January to December 2014 totally 120 cases of infectious disease including 47 neonates with severe infection combining systemic symptoms ( severe infection group ) and 73 neonates with local infection without systemic symptoms ( local infection group) were admitted in Maternal and Child Health Care Hospital in Yueqing City.They were divided into bacterial infection group (76 cases) and non-bacterial infection group (44 cases).The serum PCT and CRP levels were detected and compared among different groups.Results Compared with non-bacterial infection group, the serum CRP and PCT levels were significantly increased in severe infection group and local infection group (CRP:t=8.93,t=6.17;PCT:t=7.24,t=5.31, respectively, all P<0.05).The serum CRP and PCT levels in severe infection group were significantly increased compared with local infection group (tCRP =4.29;tPCT =5.47, respectively, both P<0.05).Compared to non-bacterial infection group, the serum CRP and PCT levels in bacterial infection group were significantly increased before treatment ( tCRP =8.49;tPCT =7.14, respectively, both P<0.05) and obviously decreased after treatment (tCRP =7.61; tPCT =6.38, respectively, both P <0.05).The sensitivity and specificity of CRP and PCT detection were improved significantly compared with WBC detection (CRP:tsensitivity =12.90,tspecificity =33.97, PCT:tsensitivity =20.95, tspecificity =50.42, respectively, all P <0.05).Conclusion The detection of CRP and PCT levels provides quick pathogenic diagnosis basis for early diagnosis and prognostic assessment of neonatal infection disease, and can dynamically observe the severity of infection and infection control.