CAJ | 학술논문

结直肠癌是胃肠道最常见的恶性肿瘤之一，发病机制尚未完全明确，目前认为是一个多步骤、多阶段参与的疾病。Wnt 信号转导通路可调控细胞生长、运动和分化，且在胚胎发育、肿瘤发生等过程中起重要作用。本文就 Wnt 信号转导通路与结直肠癌的研究进展作一综述。
결직장암시위장도최상견적악성종류지일，발병궤제상미완전명학，목전인위시일개다보취、다계단삼여적질병。Wnt 신호전도통로가조공세포생장、운동화분화，차재배태발육、종류발생등과정중기중요작용。본문취 Wnt 신호전도통로여결직장암적연구진전작일종술。
Colorectal cancer is one of the most commonly seen gastrointestinal carcinomas and its pathogenesis has not yet been fully clarified. It is considered as a multi-step and multi-stage disease. Wnt signaling transduction pathway regulates cell growth,motility and differentiation,and plays a crucial role in the regulation of embryonic development and tumor genesis. This article reviewed the advances in study on Wnt signaling transduction pathway and colorectal cancer.