胃肠病学
胃腸病學
위장병학
Chinese Journal of Gastroenterology
2015年
10期
632-634
,共3页
胃肠道%微生态%幽门螺杆菌%根除治疗
胃腸道%微生態%幽門螺桿菌%根除治療
위장도%미생태%유문라간균%근제치료
Gastrointestinal Tract%Microbiota%Helicobacter pylori%Eradication Therapy
胃肠道微生态系统庞大而复杂，影响因素众多，其中幽门螺杆菌（Hp）作为外源性细菌，可与胃肠道微生态产生相互影响。研究发现 Hp 感染可致肠道内嗜酸乳杆菌数量增多，胃内放线菌门、拟杆菌门和厚壁菌门数量减少。Hp 根除治疗方案中的质子泵抑制剂和抗菌药物亦可影响胃肠道微生态。同时，胃肠道微生态可影响 Hp 在胃黏膜的定植，在根除 Hp 时联合使用益生菌可有效提高根除率，减少不良反应。
胃腸道微生態繫統龐大而複雜，影響因素衆多，其中幽門螺桿菌（Hp）作為外源性細菌，可與胃腸道微生態產生相互影響。研究髮現 Hp 感染可緻腸道內嗜痠乳桿菌數量增多，胃內放線菌門、擬桿菌門和厚壁菌門數量減少。Hp 根除治療方案中的質子泵抑製劑和抗菌藥物亦可影響胃腸道微生態。同時，胃腸道微生態可影響 Hp 在胃黏膜的定植，在根除 Hp 時聯閤使用益生菌可有效提高根除率，減少不良反應。
위장도미생태계통방대이복잡，영향인소음다，기중유문라간균（Hp）작위외원성세균，가여위장도미생태산생상호영향。연구발현 Hp 감염가치장도내기산유간균수량증다，위내방선균문、의간균문화후벽균문수량감소。Hp 근제치료방안중적질자빙억제제화항균약물역가영향위장도미생태。동시，위장도미생태가영향 Hp 재위점막적정식，재근제 Hp 시연합사용익생균가유효제고근제솔，감소불량반응。
Gastrointestinal microbiota is a huge and complex system that has multiple influential factors. As an exogenous pathogen,Helicobacter pylori(Hp)may interact with gastrointestinal microbiota. It has been revealed that Hp infection led to an increase in Lactobacillus acidophilus in intestinal tract and a decrease in Actinobacteria,Bacteroidetes and Firmacutes in stomach. Proton pump inhibitors and antibiotics,the major components of eradication regimens for Hp infection,may also have an impact on gastrointestinal microbiota. On the other hand,gastrointestinal microbiota interferes with Hp’s attachment into gastric mucosa. Probiotics combined with eradication therapy could benefit the eradication rate of Hp infection and reduce adverse events.
