CAJ | 학술논문

炎症性肠病（IBD）是一种自身免疫性疾病，发病机制尚未明确，目前认为是由宿主基因、肠道微生物以及生活环境等因素综合作用，引发机体异常免疫应答所致。近年来，Th17细胞与 IBD 的关系成为研究热点，且越来越多的研究表明，肠道菌群对 Th17细胞及其相关细胞因子的调节与 IBD 发病密切相关。本文就 Th17细胞和肠道菌群在 IBD 发病中的作用作一综述。
염증성장병（IBD）시일충자신면역성질병，발병궤제상미명학，목전인위시유숙주기인、장도미생물이급생활배경등인소종합작용，인발궤체이상면역응답소치。근년래，Th17세포여 IBD 적관계성위연구열점，차월래월다적연구표명，장도균군대 Th17세포급기상관세포인자적조절여 IBD 발병밀절상관。본문취 Th17세포화장도균군재 IBD 발병중적작용작일종술。
Inflammatory bowel disease(IBD)is an autoimmune disease and its etiology has not yet been clarified. Dysregulated immune responses resulted from complex interactions among genetic factors,intestinal flora and environmental cues have been considered as the etiology of IBD. Recently,the relationship between Th17 cells and IBD has become a hotspot of study,and more and more studies showed that Th17 cells and their related cytokines regulated by intestinal flora contributed to the pathogenesis of IBD. This article reviewed the role of Th17 cells and intestinal flora in the pathogenesis of IBD.