中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
Chinese Journal of Woman and Child Health Research
2015年
5期
1024-1026
,共3页
黛力新%氟桂利嗪%偏头痛%脑血流动力学
黛力新%氟桂利嗪%偏頭痛%腦血流動力學
대력신%불계리진%편두통%뇌혈류동역학
deanxit%flunarizine%migraine%cerebral hemodynamics
目的：探讨黛力新联合氟桂利嗪治疗更年期女性偏头痛的疗效及对脑血流动力学的影响。方法选择120例更年期女性偏头痛患者随机分为观察组和对照组各60例，观察组给予黛力新联合氟桂利嗪进行治疗，对照组单纯给予氟桂利嗪治疗，连续治疗3个月后，比较两组患者治疗前后头痛发作频率、脑血流动力学改善情况及疗效。结果观察组治疗后头痛发作频率、头痛的疼痛视觉模拟评分法（VAS）评分均较对照组明显更低，经比较差异均有统计学意义（t发作频率＝15．095、tVAS评分＝14．114，均P＜0．05）；观察组有效率为98．33％，高于对照组的88．33％，经比较差异有统计学意义（χ2＝26．227，P＜0．05）；观察组治疗后大脑中动脉（MCA）、大脑前动脉（ACA）、大脑后动脉（PCA）、椎动脉（VERT）、基底动脉（BSLR）血流速度均较对照组明显更低，经比较差异均有统计学意义（tMCA ＝12．315、tACA ＝14．001、tPCA ＝11．082、tVERT ＝13．069、tBSLR ＝12．886，均P＜0．05）。结论黛力新联合氟桂利嗪治疗更年期女性偏头痛疗效较好，脑血流动力学指标改善明显。
目的：探討黛力新聯閤氟桂利嗪治療更年期女性偏頭痛的療效及對腦血流動力學的影響。方法選擇120例更年期女性偏頭痛患者隨機分為觀察組和對照組各60例，觀察組給予黛力新聯閤氟桂利嗪進行治療，對照組單純給予氟桂利嗪治療，連續治療3箇月後，比較兩組患者治療前後頭痛髮作頻率、腦血流動力學改善情況及療效。結果觀察組治療後頭痛髮作頻率、頭痛的疼痛視覺模擬評分法（VAS）評分均較對照組明顯更低，經比較差異均有統計學意義（t髮作頻率＝15．095、tVAS評分＝14．114，均P＜0．05）；觀察組有效率為98．33％，高于對照組的88．33％，經比較差異有統計學意義（χ2＝26．227，P＜0．05）；觀察組治療後大腦中動脈（MCA）、大腦前動脈（ACA）、大腦後動脈（PCA）、椎動脈（VERT）、基底動脈（BSLR）血流速度均較對照組明顯更低，經比較差異均有統計學意義（tMCA ＝12．315、tACA ＝14．001、tPCA ＝11．082、tVERT ＝13．069、tBSLR ＝12．886，均P＜0．05）。結論黛力新聯閤氟桂利嗪治療更年期女性偏頭痛療效較好，腦血流動力學指標改善明顯。
목적：탐토대력신연합불계리진치료경년기녀성편두통적료효급대뇌혈류동역학적영향。방법선택120례경년기녀성편두통환자수궤분위관찰조화대조조각60례，관찰조급여대력신연합불계리진진행치료，대조조단순급여불계리진치료，련속치료3개월후，비교량조환자치료전후두통발작빈솔、뇌혈류동역학개선정황급료효。결과관찰조치료후두통발작빈솔、두통적동통시각모의평분법（VAS）평분균교대조조명현경저，경비교차이균유통계학의의（t발작빈솔＝15．095、tVAS평분＝14．114，균P＜0．05）；관찰조유효솔위98．33％，고우대조조적88．33％，경비교차이유통계학의의（χ2＝26．227，P＜0．05）；관찰조치료후대뇌중동맥（MCA）、대뇌전동맥（ACA）、대뇌후동맥（PCA）、추동맥（VERT）、기저동맥（BSLR）혈류속도균교대조조명현경저，경비교차이균유통계학의의（tMCA ＝12．315、tACA ＝14．001、tPCA ＝11．082、tVERT ＝13．069、tBSLR ＝12．886，균P＜0．05）。결론대력신연합불계리진치료경년기녀성편두통료효교호，뇌혈류동역학지표개선명현。
Objective To explore the therapeutic effect of deanxit combined with flunarizine for menopausal women with migraine and its influence on cerebral hemodynamics indicators.Methods Totally 120 menopausal women with migraine were randomly divided into observation group and control group with 60 cases in each.The observation group was treated with deanxit combined with flunarizine, while the control group was treated with flunarizine only.After 3 months of continuous treatment, headache frequency and improvement of cerebral hemodynamics before and after treatment were compared between two groups.Results The headache frequency and headache VAS score of the observation group were significantly lower than those of the control group, and the differences were statistically significant ( t value was 15.095 and 14.114,respectively, both P<0.05).The effective rate of the observation group (98.33%) was higher than that of the control group (88.33%) with significant difference (χ2 =26.227,P<0.05).After treatment, blood flow velocity of MCA, ACA, PCA, VERT and BSLR in the observation group were significantly lower than those in the control group, and the differences were significant (t value was 12.315, 14.001, 11.082, 13.069 and 12.886, respectively, all P<0.05).Conclusion Deanxit combined with flunarizine in the treatment of migraine in menopausal women has significant effect and can significantly improve cerebral hemodynamics indicators.
