临床与病理杂志
臨床與病理雜誌
림상여병리잡지
International Journal of Pathology and Clinical Medicine
2015年
10期
1842-1846
,共5页
蔡云东(综述)%费爱华(审校)
蔡雲東(綜述)%費愛華(審校)
채운동(종술)%비애화(심교)
万古霉素%药物浓度监测%药代动力学
萬古黴素%藥物濃度鑑測%藥代動力學
만고매소%약물농도감측%약대동역학
vancomycin%minimum inhibit concentration%pharmacokinetics
万古霉素能有效治疗革兰阳性菌尤其是耐甲氧西林金葡菌(methicillin-resistant staphylococcus aureus，MRSA)引起的感染。但影响万古霉素临床疗效因素较多，临床上可通过监测万古霉素血药浓度、最低抑菌浓度(minimal inhibitory concentration，MIC)及肾功能等，以调节万古霉素用药剂量及时间间隔，提高疗效并尽可能降低不良反应的发生。
萬古黴素能有效治療革蘭暘性菌尤其是耐甲氧西林金葡菌(methicillin-resistant staphylococcus aureus，MRSA)引起的感染。但影響萬古黴素臨床療效因素較多，臨床上可通過鑑測萬古黴素血藥濃度、最低抑菌濃度(minimal inhibitory concentration，MIC)及腎功能等，以調節萬古黴素用藥劑量及時間間隔，提高療效併儘可能降低不良反應的髮生。
만고매소능유효치료혁란양성균우기시내갑양서림금포균(methicillin-resistant staphylococcus aureus，MRSA)인기적감염。단영향만고매소림상료효인소교다，림상상가통과감측만고매소혈약농도、최저억균농도(minimal inhibitory concentration，MIC)급신공능등，이조절만고매소용약제량급시간간격，제고료효병진가능강저불량반응적발생。
Vancomycin is widely used antibiotic which treat infection caused by Gram-positive bacteria like MRSA. A vast of factors in clinic practice can alter the effcacy of vancomycin. It is accepted that detecting concentration of vancomycin in blood, minimum inhibit concentration (MIC) and creatinine clearance rate is necessary for adjusting the dose and time of vancomycin, which is responsible for good effcacy and reduced side effects.
