临床与病理杂志
臨床與病理雜誌
림상여병리잡지
International Journal of Pathology and Clinical Medicine
2015年
10期
1857-1866
,共10页
丁梦珊%李朋朋(综述)%马萍%姜飞%顾兵(审校)
丁夢珊%李朋朋(綜述)%馬萍%薑飛%顧兵(審校)
정몽산%리붕붕(종술)%마평%강비%고병(심교)
鲍曼不动杆菌%耐药性%碳青霉烯酶基因%传播形式
鮑曼不動桿菌%耐藥性%碳青黴烯酶基因%傳播形式
포만불동간균%내약성%탄청매희매기인%전파형식
Acinetobacter baumannii(Ab)%resistance%carbapenemase gene%transmission
鲍曼不动杆菌是革兰阴性杆菌中最常见的条件致病菌之一，近年来对碳青霉烯类抗菌药耐药性逐渐增强，导致较高的发病率和病死率。其耐药机制较为复杂，产碳青霉烯酶是其对碳青霉烯类抗菌药耐药的主要机制。本文主要从三个方面进行阐述：第一，鲍曼不动杆菌对亚胺培南和美罗培南的耐药性；第二，A类、B类和D类碳青霉烯酶及其基因的进展；第三，耐药质粒、转座子、整合子和插入序列介导的耐碳青霉烯类鲍曼不动杆菌的传播形式。
鮑曼不動桿菌是革蘭陰性桿菌中最常見的條件緻病菌之一，近年來對碳青黴烯類抗菌藥耐藥性逐漸增彊，導緻較高的髮病率和病死率。其耐藥機製較為複雜，產碳青黴烯酶是其對碳青黴烯類抗菌藥耐藥的主要機製。本文主要從三箇方麵進行闡述：第一，鮑曼不動桿菌對亞胺培南和美囉培南的耐藥性；第二，A類、B類和D類碳青黴烯酶及其基因的進展；第三，耐藥質粒、轉座子、整閤子和插入序列介導的耐碳青黴烯類鮑曼不動桿菌的傳播形式。
포만불동간균시혁란음성간균중최상견적조건치병균지일，근년래대탄청매희류항균약내약성축점증강，도치교고적발병솔화병사솔。기내약궤제교위복잡，산탄청매희매시기대탄청매희류항균약내약적주요궤제。본문주요종삼개방면진행천술：제일，포만불동간균대아알배남화미라배남적내약성；제이，A류、B류화D류탄청매희매급기기인적진전；제삼，내약질립、전좌자、정합자화삽입서렬개도적내탄청매희류포만불동간균적전파형식。
Acinetobacter baumannii(Ab)is one of the most common opportunistic pathogens in gram-negative bacteria, while carbapenem antimicrobial resistance is gradually increasing in recent years. Morbidity and mortality associated withA. baumanniiInfection are increasing. Its resistance mechanism is more complex, and making carbapenemases is the main resistance mechanism ofA. baumanniito carbapenem. This article elaborates mainly from the following three aspects: ifrstly, the antimicrobial resistance ofA. baumanniito imipenem and meropenem; secondly, the progress of class A, Class B and class D carbapenemases and their genes; thirdly, the transmission of carbapenem-resisitantA. baumannii mediated between resistance plasmid, transposon-mediated,integronand insertion sequence.
