中国实用医药
中國實用醫藥
중국실용의약
China Practical Medical
2015年
33期
283-285
,共3页
n-3 脂肪酸%胰腺炎%核因子 κB
n-3 脂肪痠%胰腺炎%覈因子 κB
n-3 지방산%이선염%핵인자 κB
n-3 fatty acid%Pancreatitis%Nuclear factor κBB
目的：探讨 n-3脂肪酸对大鼠重症急性胰腺炎(SAP)早期调控机制。方法30只 SD 大鼠随机分为正常组(开腹后翻动胰腺数次后尾静脉注射生理盐水)、治疗组(造模成功后，尾静脉注射n-3脂肪酸)和 SAP 组(造膜成功后，尾静脉注射生理盐水)，各10例，并3 h 取材。观察血清丙二醛(MDA)、淀粉酶(AMY)、超氧化物歧化酶(SOD)，胰腺核因子κB(NF-κB)及病理损伤。结果 SAP 组血清 MDA、AMY、胰腺 NF-κB 及病理损伤明显高于治疗组和正常组(P<0.05)，治疗组这些指标均高于正常组(P<0.05)；而 SOD 在正常组明显高于治疗组和 SAP 组(P<0.05)，治疗组明显高于 SAP 组(P<0.05)。结论 n-3脂肪酸是一种免疫调理营养脂肪乳剂，早期具有调节炎症反应，减少氧自由基生产，减轻胰腺组织损伤，对胰腺炎具有一定保护作用。
目的：探討 n-3脂肪痠對大鼠重癥急性胰腺炎(SAP)早期調控機製。方法30隻 SD 大鼠隨機分為正常組(開腹後翻動胰腺數次後尾靜脈註射生理鹽水)、治療組(造模成功後，尾靜脈註射n-3脂肪痠)和 SAP 組(造膜成功後，尾靜脈註射生理鹽水)，各10例，併3 h 取材。觀察血清丙二醛(MDA)、澱粉酶(AMY)、超氧化物歧化酶(SOD)，胰腺覈因子κB(NF-κB)及病理損傷。結果 SAP 組血清 MDA、AMY、胰腺 NF-κB 及病理損傷明顯高于治療組和正常組(P<0.05)，治療組這些指標均高于正常組(P<0.05)；而 SOD 在正常組明顯高于治療組和 SAP 組(P<0.05)，治療組明顯高于 SAP 組(P<0.05)。結論 n-3脂肪痠是一種免疫調理營養脂肪乳劑，早期具有調節炎癥反應，減少氧自由基生產，減輕胰腺組織損傷，對胰腺炎具有一定保護作用。
목적：탐토 n-3지방산대대서중증급성이선염(SAP)조기조공궤제。방법30지 SD 대서수궤분위정상조(개복후번동이선수차후미정맥주사생리염수)、치료조(조모성공후，미정맥주사n-3지방산)화 SAP 조(조막성공후，미정맥주사생리염수)，각10례，병3 h 취재。관찰혈청병이철(MDA)、정분매(AMY)、초양화물기화매(SOD)，이선핵인자κB(NF-κB)급병리손상。결과 SAP 조혈청 MDA、AMY、이선 NF-κB 급병리손상명현고우치료조화정상조(P<0.05)，치료조저사지표균고우정상조(P<0.05)；이 SOD 재정상조명현고우치료조화 SAP 조(P<0.05)，치료조명현고우 SAP 조(P<0.05)。결론 n-3지방산시일충면역조리영양지방유제，조기구유조절염증반응，감소양자유기생산，감경이선조직손상，대이선염구유일정보호작용。
Objective To investigate n-3 fatty acid for early regulatory mechanism in severe acute pancreatitis (SAP). Methods A total of 30 SD rats were randomly divided into normal group (normal saline by tail intravenous injection after pancreas flipped for several time in laparotomy), treatment group (n-3 fatty acid by tail intravenous injection after molding) and SAP group (normal saline by tail intravenous injection after molding), with 10 cases in each group. Observations were made on serum methane dicarboxylic aldehyde (MDA), amylase (AMY), superoxide dismutase (SOD), pancreas nuclear factor κB (NF-κB), and pathological damage. Results SAP group had obviously higher serum MDA, AMY, pancreas NF-κB, and pathological damage than treatment group and normal group (P<0.05). These indexes were also higher in treatment group than in normal group (P<0.05). Normal group had much higher SOD than treatment group and SAP group (P<0.05). Treatment group had much higher SOD than SAP group (P<0.05). Conclusion As a nutrition fat emulsion for immune regulation, n-3 fatty acid can regulate early inflammatory reaction, reduce occurrence oxygen radical, and decrease pancreatic tissue damage. It also contains certain protective effect for pancreatitis.
