CAJ | 학술논문

来源于早期外胚间充质组织头部的神经嵴细胞迁移衍生出牙髓间充质干细胞，随后这些细胞产生牙髓细胞和成牙本质细胞。神经胶质细胞是另外一个神经嵴细胞衍生迁移而形成的细胞系。神经胶质细胞有广泛的分化发育潜能，研究发现神经胶质细胞可以分化为神经细胞和牙髓间充质干细胞，并且神经胶质细胞的不同分化发育阶段间可以互相转变。通常认为，大多数组织中的间充质干细胞来源于血管周细胞，但有研究发现相当一部分牙髓间充质干细胞来源于外周神经相关的神经胶质。本文通过对神经嵴细胞、牙髓间充质干细胞和神经胶质细胞的分化发育以及神经胶质细胞的衍生细胞的概述，介绍牙髓再生领域一种新的更有前景的牙髓间充质干细胞来源。
래원우조기외배간충질조직두부적신경척세포천이연생출아수간충질간세포，수후저사세포산생아수세포화성아본질세포。신경효질세포시령외일개신경척세포연생천이이형성적세포계。신경효질세포유엄범적분화발육잠능，연구발현신경효질세포가이분화위신경세포화아수간충질간세포，병차신경효질세포적불동분화발육계단간가이호상전변。통상인위，대다수조직중적간충질간세포래원우혈관주세포，단유연구발현상당일부분아수간충질간세포래원우외주신경상관적신경효질。본문통과대신경척세포、아수간충질간세포화신경효질세포적분화발육이급신경효질세포적연생세포적개술，개소아수재생영역일충신적경유전경적아수간충질간세포래원。
Dental mesenchymal stem cells derive from neural crest cells after migrating from the early head of ectomesenchymal tissue. They later give rise to pulp cells and odontoblasts. Glial cells are another cell lineage neural crest cells derived. With surprisingly broad developmental potential,glial cells can differentiate to many cell types such as neurons and dental mesenchymal stem cells. Besides,glial cells from different developmental stages are interchangeable. Current consensus holds that perivascular cells form mesenchymal stem cells in most tissues. However,recent researches show that a few dental mesenchymal stem cells are derived from peripheral nerve?associated glia. This review aims to introduce a new and prospective origin of dental mesenchymal stem cells for dentistry regeneration by summaring the development of neural crest cells,dental mesenchymal stem cells and glial cells as well as glial cell derived cells.