CAJ | 학술논문

目的 :评价规律性有氧运动对成年人血浆中 IL-6浓度的影响效果.方法 :电子检索 PubMed、Embase、Web of Science、万方、维普和知网数据库 ,检索期限均从各个数据库收录起始年限起至2014年12月 ,全面收集规律性有氧运动影响成人血浆中 IL-6浓度的随机对照实验(RCT ) ,Cochrane偏倚风险评估工具评价纳入研究的方法学质量 ,Stata 13 .0软件进行统计分析.结果 :共纳入32个RCT ,2 768个成年人 ,其中 ,慢性炎症性疾病患者670人.纳入研究中较高等级的方法学质量的研究有10个、中等研究质量12个、低等质量10个.Meta分析结果显示 ,规律性有氧运动可明显降低成年人血浆中 IL-6 浓度 ,SMD= -0 .42 (95% CI :-0 .62~ -0 .18 ,P= 0 .001 ) ,但异质性较为明显( I2 = 88 .1% ).通过 Meta回归分析排除健康状态及其他可能的混杂因素影响后 ,异质性有所降低( I2 =58 .34% ).进一步的亚组分析结果提示 ,规律性有氧运动对健康成年人血浆 IL-6 浓度的降低效果不明显(SMD= -0 .189 ,95% CI :-0 .412~0 .035 ,P= 0 .098 ) ,但对肥胖和炎症相关的慢性病患者的降低效果显著 ,其 SMD (95CI% )分别为 -0 .593 ( -1 .137 ~ -0 .05 ,P= 0 .032)和-0 .717 (-1 .324~ -0 .1 2 3 ,P=0 .0 2 1 ).结论 :规律性有氧运动能够有效降低成年人血浆中IL-6浓度 ,尤其对炎症性慢性病患者效果更为显著 ,但由于异质性和发表偏倚的影响 ,结论尚需开展更多高质量的研究加以验证.
목적 :평개규률성유양운동대성년인혈장중 IL-6농도적영향효과.방법 :전자검색 PubMed、Embase、Web of Science、만방、유보화지망수거고 ,검색기한균종각개수거고수록기시년한기지2014년12월 ,전면수집규률성유양운동영향성인혈장중 IL-6농도적수궤대조실험(RCT ) ,Cochrane편의풍험평고공구평개납입연구적방법학질량 ,Stata 13 .0연건진행통계분석.결과 :공납입32개RCT ,2 768개성년인 ,기중 ,만성염증성질병환자670인.납입연구중교고등급적방법학질량적연구유10개、중등연구질량12개、저등질량10개.Meta분석결과현시 ,규률성유양운동가명현강저성년인혈장중 IL-6 농도 ,SMD= -0 .42 (95% CI :-0 .62~ -0 .18 ,P= 0 .001 ) ,단이질성교위명현( I2 = 88 .1% ).통과 Meta회귀분석배제건강상태급기타가능적혼잡인소영향후 ,이질성유소강저( I2 =58 .34% ).진일보적아조분석결과제시 ,규률성유양운동대건강성년인혈장 IL-6 농도적강저효과불명현(SMD= -0 .189 ,95% CI :-0 .412~0 .035 ,P= 0 .098 ) ,단대비반화염증상관적만성병환자적강저효과현저 ,기 SMD (95CI% )분별위 -0 .593 ( -1 .137 ~ -0 .05 ,P= 0 .032)화-0 .717 (-1 .324~ -0 .1 2 3 ,P=0 .0 2 1 ).결론 :규률성유양운동능구유효강저성년인혈장중IL-6농도 ,우기대염증성만성병환자효과경위현저 ,단유우이질성화발표편의적영향 ,결론상수개전경다고질량적연구가이험증.
Objective :To evaluate the effect of aerobatic exercise for plasma IL-6 levels in a-dults .Methods :The randomized controlled trials (RCTs) of aerobatic exercise for plasma IL-6 level in adults were identified from PubMed ,Embase ,Web of Science ,Wanfang Data ,CNKI and VIP Data (from inception to December ,2014 ) .The methodological quality of included RCTs was assessed by the Cochrane collaboration's tool for assessing risk of bias .The Meta analysis was performed by using STATA 13 .0 software .Results :Among 32 included RCTs involving 2 768 adults (of them ,including 670 patients with chronic inflammatory diseases) , 10 RCTs were graded as high methodological quality ,12 graded as moderate degree ,and other 10 as low degree of methodological quality .The pooled result showed that aerobatic exercises were benefit to decrease plasma IL-6 levels in adults ,and the SMD= -0 .42 (95% CI :-0 .62~ -0 .18 ,P= 0 .001) ,but the heterogenicity was substantive with I2= 88 .1% .The hetero-genicity was decreased to 58 .34% by adjusted for the possible bias factors such as the partici-pants' health status ,the average of age ,the type of comparison between groups ,the duration of aerobatic exercise and quality of study by using Meta regression .The sub-group analysis suggested that effect of aerobatic exercise decreasing plasma IL-6 levels was more effective in patients with chronic inflammatory diseases or the obese individuals than the healthy adults , and SWD (95% CI) was -0 .717( -1 .324~ -0 .123 ,P= 0 .021) ,-0 .593(-1 .137 ~-0 .05 ,P= 0 .032 ) and -0 .189 (-0 .412~ 0 .035 ,P= 0 .098 ) ,respectively .Conclusion :Current evidence shows that regular aerobatic exercises are effective to decrease plasma IL-6 levels in adults ,especially in patients with chronic inflammatory diseases .However ,more high-quality studies are required to verify the conclusion of this study due to the obvious heteroge-nicity and publication bias .