河北医药
河北醫藥
하북의약
Hebei Medical Journal
2015年
21期
3215-3218
,共4页
子宫内膜癌%甲基化%TβRⅠ%TβRⅡ
子宮內膜癌%甲基化%TβRⅠ%TβRⅡ
자궁내막암%갑기화%TβRⅠ%TβRⅡ
endometrial cancer%methylation%TβRⅠ%TβRⅡ
目的:探讨TβRⅠ和TβRⅡ基因甲基化与子宫内膜癌发生发展的关系。方法应用改进的甲基化特异性聚合酶链式反应( MSP)技术检测60例子宫内膜癌组织及60例癌旁正常组织中TβRⅠ、TβRⅡ基因启动子甲基化情况,分析两基因启动子甲基化与各临床指标之间的关系。结果 TβRⅠ在子宫内膜癌组和癌旁正常组的甲基化率分别为75 q.0%(45/60)和45.0%(27/60),子宫内膜癌组的甲基化率显著高于癌旁正常组(χ2=11.250, P =0.001)。 TβRⅡ在子宫内膜癌组和癌旁正常组的甲基化率分别为68.3%(41/60)和36.7%(22/60),子宫内膜癌组的甲基化率显著高于癌旁正常组(χ2=12.063, P =0.000)。两基因启动子甲基化与临床指标差异无统计学意义(P>0.05)。结论 TβRⅠ和TβRⅡ基因启动子甲基化可能与子宫内膜癌的发生有关。
目的:探討TβRⅠ和TβRⅡ基因甲基化與子宮內膜癌髮生髮展的關繫。方法應用改進的甲基化特異性聚閤酶鏈式反應( MSP)技術檢測60例子宮內膜癌組織及60例癌徬正常組織中TβRⅠ、TβRⅡ基因啟動子甲基化情況,分析兩基因啟動子甲基化與各臨床指標之間的關繫。結果 TβRⅠ在子宮內膜癌組和癌徬正常組的甲基化率分彆為75 q.0%(45/60)和45.0%(27/60),子宮內膜癌組的甲基化率顯著高于癌徬正常組(χ2=11.250, P =0.001)。 TβRⅡ在子宮內膜癌組和癌徬正常組的甲基化率分彆為68.3%(41/60)和36.7%(22/60),子宮內膜癌組的甲基化率顯著高于癌徬正常組(χ2=12.063, P =0.000)。兩基因啟動子甲基化與臨床指標差異無統計學意義(P>0.05)。結論 TβRⅠ和TβRⅡ基因啟動子甲基化可能與子宮內膜癌的髮生有關。
목적:탐토TβRⅠ화TβRⅡ기인갑기화여자궁내막암발생발전적관계。방법응용개진적갑기화특이성취합매련식반응( MSP)기술검측60례자궁내막암조직급60례암방정상조직중TβRⅠ、TβRⅡ기인계동자갑기화정황,분석량기인계동자갑기화여각림상지표지간적관계。결과 TβRⅠ재자궁내막암조화암방정상조적갑기화솔분별위75 q.0%(45/60)화45.0%(27/60),자궁내막암조적갑기화솔현저고우암방정상조(χ2=11.250, P =0.001)。 TβRⅡ재자궁내막암조화암방정상조적갑기화솔분별위68.3%(41/60)화36.7%(22/60),자궁내막암조적갑기화솔현저고우암방정상조(χ2=12.063, P =0.000)。량기인계동자갑기화여림상지표차이무통계학의의(P>0.05)。결론 TβRⅠ화TβRⅡ기인계동자갑기화가능여자궁내막암적발생유관。
Objective To investigate the correlation between methylation of transforming growth factorβreceptorⅠ,Ⅱ(TβRⅠ,Ⅱ) gene and pathogenesis, development of endometrial cancer (EC).Methods The modified methylation specific PCR ( MSP) was used to detect the methylation status of TβRⅠ,Ⅱgene promoter in 60 cases of EC tissues and 60 cases of adjacent non-cancerous tissues.The correlation between the methylation of two gene promotors and clinical indexes was analyzed.Results The mathylation rate of TβRⅠin EC tissues and adjacent non-cancerous tissues was 75%(45/60) and 45% ( 27/60 ) , respectively. The methylation rate of EC tissues was significantly higher than that of adjacent non-cancerous tissues (χ2 =11.25, P <0.01).The mathylation rate of TβRⅡ in EC tissues and adjacent non-cancerous tissues was 68.3%(41/60) and 36.7%(22/60),respectively.The methylation rate of EC tissues was significantly higher than that of adjacent non-cancerous tissues (χ2 =12.06, P <0.01 ) .However there was no correlation between the methylation of two gene promotors and clinical indexes ( P >0.05).Conclusion The methylation of TβRⅠand TβRⅡpromoters may be correlated to the pathogenesis of EC.