CAJ | 학술논문

细胞自噬作为骨骼肌必需的代偿性内置调节机制 ,可在运动、禁食、营养限制和肌肉收缩刺激等能量应激下 ,将胞浆中损伤或衰老的细胞组件(线粒体、内质网、核糖体)、病菌和ROS等代谢废物 ,以及糖原、脂质、非功能或功能性蛋白质等能源物质 ,转运到溶酶体中消化降解 ,从而完善骨骼肌细胞质量控制 ,有效供给细胞更新和代谢平衡所需的能量与合成底物的一种分解代谢装置.运动训练不仅能通过细胞自噬完善骨骼肌线粒体质量控制 ,稳定线粒体功能网络 ,维持骨骼肌代谢稳态 ,还能有效防治胰岛素抵抗、肥胖和 Ⅱ型糖尿病等代谢疾病的发生.运动训练介导的细胞自噬也可使骨骼肌质量及其功能根据运动项目的自身特点进行积极调整和适应 ,从而进一步维持骨骼肌代谢功能稳态.
세포자서작위골격기필수적대상성내치조절궤제 ,가재운동、금식、영양한제화기육수축자격등능량응격하 ,장포장중손상혹쇠로적세포조건(선립체、내질망、핵당체)、병균화ROS등대사폐물 ,이급당원、지질、비공능혹공능성단백질등능원물질 ,전운도용매체중소화강해 ,종이완선골격기세포질량공제 ,유효공급세포경신화대사평형소수적능량여합성저물적일충분해대사장치.운동훈련불부능통과세포자서완선골격기선립체질량공제 ,은정선립체공능망락 ,유지골격기대사은태 ,환능유효방치이도소저항、비반화 Ⅱ형당뇨병등대사질병적발생.운동훈련개도적세포자서야가사골격기질량급기공능근거운동항목적자신특점진행적겁조정화괄응 ,종이진일보유지골격기대사공능은태.
As a compensatory and built-in mechanism of skeletal muscle ,autophagy not only could degrade reactive oxygen species ,bacteria ,aging or damaged organelles such as mitochon-dria ,endoplasmic reticulum ,ribosome ,as well as degrade glycogen ,lipid ,non-functional and functional protein when suffer energy stress such as exercise ,fasting ,nutrition restriction and muscle contraction .Autophagy accordingly could improve muscle quality control ,as well as en-ergy and synthetic substrates for cellular renewal and metabolism .Exercise training-mediated autophagy not only could improve mitochondrial quality control ,stabilize mitochondrial function network ,as well as maintain metabolic homeostasis of muscle ,but also effectively prevent insu-lin resistance ,obesity ,type Ⅱ diabetes and some other metabolic diseases .Exercise training-me-diated autophagy could also entirely adapt muscle mass and function to their items ,and further improve muscle metabolism and functional homeostasis .