CAJ | 학술논문

目的：探讨直肠癌的动态增强磁共振成像（DCE-MRI）的各参数指标与直肠癌分化程度的相关性。方法：40例经病例证实的直肠癌患者进行 DCE-MRI 成像，应用 Tofts 模型后处理得到感兴趣区的微循环参数 Ktrans 、Kep 、Ve 及iAUC 值，与术后病理分化程度进行 Kruskal-Wallis 秩和检验，Pearson 秩相关性分析。同时选取15例未患直肠癌的对照组，将其与患者组的动态增强参数进行对照。结果：患者组病灶的 Ktrans 值、Kep 值、Ve 值、iAUC 值均高于对照组，2组间差异有统计学意义（P ＜0．05）。直肠癌病灶的时间-信号强度曲线表现为流出型。40例直肠癌术后病理结果 G1级6例，G2级21例，G3级13例。不同病理 G 分级组间 Ktrans 值、Kep 值、iAUC 值差异有统计学意义（P 均＜0．05）；Ktrans 值、iAUC 值与 G 分级有相关性（P ＜0．05）。结论：磁共振动态增强成像能反映直肠癌的微循环差异，其参数指标在一定程度上与直肠癌分化程度有相关性。
목적：탐토직장암적동태증강자공진성상（DCE-MRI）적각삼수지표여직장암분화정도적상관성。방법：40례경병예증실적직장암환자진행 DCE-MRI 성상，응용 Tofts 모형후처리득도감흥취구적미순배삼수 Ktrans 、Kep 、Ve 급iAUC 치，여술후병리분화정도진행 Kruskal-Wallis 질화검험，Pearson 질상관성분석。동시선취15례미환직장암적대조조，장기여환자조적동태증강삼수진행대조。결과：환자조병조적 Ktrans 치、Kep 치、Ve 치、iAUC 치균고우대조조，2조간차이유통계학의의（P ＜0．05）。직장암병조적시간-신호강도곡선표현위류출형。40례직장암술후병리결과 G1급6례，G2급21례，G3급13례。불동병리 G 분급조간 Ktrans 치、Kep 치、iAUC 치차이유통계학의의（P 균＜0．05）；Ktrans 치、iAUC 치여 G 분급유상관성（P ＜0．05）。결론：자공진동태증강성상능반영직장암적미순배차이，기삼수지표재일정정도상여직장암분화정도유상관성。
Objective:To investigate the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in evaluation of rectal cancer,and explore the correlation between the parameters and rectal cancer pathologicaldifferentiation.Methods:4 0 patients with histologically proven rectal cancer were studied by preoperative DCE-MRI.All ofthe data were transferred to workstation for analyzing the microcirculation parameters of region of interest by using theTofts model,which included Ktrans ,Kep ,Ve and iAUC,then they were compared with postoperative pathology,the resultswere statistically analyzed.1 5 patients without rectal cancer were selected and compared with the cancer group.Results:TheKtrans ,Kep ,Ve,iAUC of the rectal cancer were higher than those of the normal group (P <0.05 ).The time-signal intensitycurve belonged to the outflow type.The postoperative pathological results:6 cases were G1,21 cases were G2,1 3 cases wereG3 .The Ktrans and iAUC had a positive correlation with the degree of pathological differentiation,P <0.05 .Conclusion:Theparameters of DCE-MRI can reflect the difference of blood supply in different tissues of the rectal cancer and have certaineffect in the evaluation of the differentiation degree.